Complex nano-systems for highly selective imaging and targeting of cells

用于高选择性成像和细胞靶向的复杂纳米系统

• 批准号: DP160104196
• 负责人: Prof Thomas Davis
• 金额: $ 30.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-03-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104196
• 关键词: Complex; nano; systems; highly; selective

The aim of the project is to design multi-functional nanoparticles that can be tracked by multiple bio-imaging techniques, such as magnetic resonance imaging (MRI) and positron emission tomography imaging. The nanoparticles are designed to be targetable to specific cell populations and capable of delivering drugs. The project plans to concentrate the MRI-active gadolinium into nanoparticles to generate enhanced images, and to combine this with other imaging modalities to facilitate tracking and sensitivity. Expected outcomes would enable a new approach to extremely accurate and sensitive imaging of tumours to enable the imaging of much smaller tumours than currently possible. This would allow early therapeutic intervention. The nanoparticles are also designed to deliver a therapeutic payload to specific locations, avoiding systemic delivery of toxic anticancer drugs.

该项目的目的是设计多功能纳米颗粒，可以通过磁共振成像(MRI)和正电子发射断层成像等多种生物成像技术进行追踪。这种纳米颗粒被设计成可以针对特定的细胞群体，并能够输送药物。该项目计划将具有核磁共振活性的Gd浓缩成纳米颗粒，以产生增强的图像，并将其与其他成像方式结合起来，以促进跟踪和灵敏度。预期的结果将使一种新的方法能够极其准确和敏感地对肿瘤进行成像，从而能够对比目前可能的小得多的肿瘤进行成像。这将允许及早进行治疗干预。这些纳米颗粒还被设计成将治疗有效载荷输送到特定位置，避免全身输送有毒的抗癌药物。