A study of the interrelationships between drug release and polymer biodegradation of novel drug-polymer conjugates (DPCs)

新型药物-聚合物缀合物（DPC）的药物释放与聚合物生物降解之间相互关系的研究

• 批准号: LP140100284
• 负责人: Prof Thomas Davis
• 金额: $ 31.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-10-03 至 2017-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100284
• 关键词: study; interrelationships; between; drug; release

This project involves a comprehensive investigation of novel polyurethane based drug-polymer conjugates. A variety of components will be scrutinised using a modular approach for assembling the drug conjugated devices, resulting in different polymer biodegradation characteristics, drug release rates and physical properties. The project aims to provide key knowledge about the inter-relationships between the key elements so that each can be precisely tailored to meet the specific requirements of a particular biological site and drug. Ultimately, this study intends to lead to the production of new drug-carrier polymer devices suitable for the treatment of illnesses and diseases.

本项目涉及一种新型的以聚氨酯为基础的药物-聚合物结合物的全面研究。将使用模块化方法仔细检查各种组件，以组装药物结合装置，从而产生不同的聚合物生物降解特性、药物释放速率和物理特性。该项目旨在提供关于关键要素之间相互关系的关键知识，以便每个要素都能精确地适应特定生物场所和药物的具体要求。最终，这项研究旨在生产适用于治疗疾病的新型药物载体聚合物装置。