Bacterial Cell Division: Discovering how it begins and the network of protein interactions it requires.

细菌细胞分裂：发现它是如何开始的以及它所需的蛋白质相互作用网络。

• 批准号: DP0450770
• 负责人: Prof Elizabeth Harry
• 金额: $ 20.89万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-04-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450770
• 关键词: Bacterial; Cell; Division; Discovering; how

All cells must coordinate cell division with chromosome replication to ensure that the DNA is partitioned equally into newborn cells. We will establish the defect of a novel mutant blocked in the earliest stage of cell division in bacteria to obtain unique information about this vital regulatory step. We will use our newly discovered protein interaction network to establish what role protein interactions play in integrating cell division with other biological pathways in the cell to ensure its tight regulation. Our discoveries will facilitate the design of new antibiotics that target cell division to fight antibiotic-resistant bacteria and bioterrorism organisms.

所有细胞都必须协调细胞分裂和染色体复制，以确保DNA均匀地分配到新生细胞中。我们将建立一种新的突变体的缺陷，在细菌细胞分裂的最早阶段被阻断，以获得关于这一重要调控步骤的独特信息。我们将使用我们新发现的蛋白质相互作用网络来确定蛋白质相互作用在整合细胞分裂与细胞中其他生物途径以确保其严格调控中发挥的作用。我们的发现将有助于设计新的抗生素，靶向细胞分裂，以对抗抗药性细菌和生物恐怖主义生物。