Bacterial Cell Division: Discovering how it begins and the network of protein interactions it requires.

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All cells must coordinate cell division with chromosome replication to ensure that the DNA is partitioned equally into newborn cells. We will establish the defect of a novel mutant blocked in the earliest stage of cell division in bacteria to obtain unique information about this vital regulatory step. We will use our newly discovered protein interaction network to establish what role protein interactions play in integrating cell division with other biological pathways in the cell to ensure its tight regulation. Our discoveries will facilitate the design of new antibiotics that target cell division to fight antibiotic-resistant bacteria and bioterrorism organisms.