Bacterial filamentation as a survival strategy: a goldmine for the discovery of new cell division regulators

细菌丝化作为一种​​生存策略：发现新细胞分裂调节剂的金矿

• 批准号: DP1093634
• 负责人: Prof Elizabeth Harry
• 金额: $ 20.9万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1093634
• 关键词: Bacterial; filamentation; survival; strategy; goldmine

The increasing emergence of untreatable bacterial infections is a serious threat to the health of Australians. Medical advances (organ transplants, chemotherapy), increases in diabetes, and an aging population increase the risk of infections caused by bacteria that are now resistant to most available antibiotics. New classes of antibiotics are urgently needed to treat these infections. This project uses a novel approach to identify the mechanisms bacterial cells use to control their growth and avoid attack by our immune system. The research will identify potential targets for the development of new, effective antibiotics to kill multi-resistant bacteria, and ensure Australia's position at the forefront of infection control.

越来越多的无法治愈的细菌感染对澳大利亚人的健康构成严重威胁。医学进步（器官移植，化疗），糖尿病的增加和人口老龄化增加了由细菌引起的感染的风险，这些细菌现在对大多数可用的抗生素具有耐药性。迫切需要新型抗生素来治疗这些感染。该项目使用一种新方法来识别细菌细胞控制其生长并避免免疫系统攻击的机制。该研究将确定开发新的有效抗生素的潜在目标，以杀死多重耐药细菌，并确保澳大利亚在感染控制方面的领先地位。