The role of central carbon metabolism in cell cycle control in bacteria

中心碳代谢在细菌细胞周期控制中的作用

• 批准号: DP150102062
• 负责人: Prof Elizabeth Harry
• 金额: $ 28.52万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102062
• 关键词: role; central; carbon; metabolism; cell

Bacteria are simple organisms, yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. The new discovery of a link between the food bacteria eat and the first stage of their cell division now provides the opportunity to elucidate how bacteria 'measure' their energy production to control their proliferation. This project combines the latest technology with complementary expertise in bacterial cell division and metabolism. This should identify the mechanism that integrates these fundamental pathways in bacteria, crucial to both their survival and ability to cause infection.

细菌是简单的有机体，但我们仍然不明白它们是如何如此忠实地一代又一代地协调生长和繁殖，以产生有活力的新生细胞的。细菌所吃的食物与其细胞分裂的第一阶段之间的联系的新发现，现在为阐明细菌如何“测量”它们的能量产生以控制它们的增殖提供了机会。该项目将最新技术与细菌细胞分裂和代谢方面的互补专业知识结合起来。这将确定整合细菌中这些基本途径的机制，这对它们的生存和引起感染的能力都至关重要。