The role of central carbon metabolism in cell cycle control in bacteria

细菌是简单的有机体，但我们仍然不明白它们是如何如此忠实地一代又一代地协调生长和繁殖，以产生有活力的新生细胞的。细菌进食的食物与其细胞分裂的第一阶段之间的联系的新发现，现在为阐明细菌如何“测量”它们的能量产生以控制它们的繁殖提供了机会。该项目结合了细菌细胞分裂和新陈代谢方面的最新技术和互补专业知识。这应该确定在细菌中整合这些基本途径的机制，这些途径对细菌的生存和导致感染的能力都至关重要。

Bacteria are simple organisms, yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. The new discovery of a link between the food bacteria eat and the first stage of their cell division now provides the opportunity to elucidate how bacteria 'measure' their energy production to control their proliferation. This project combines the latest technology with complementary expertise in bacterial cell division and metabolism. This should identify the mechanism that integrates these fundamental pathways in bacteria, crucial to both their survival and ability to cause infection.