Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets

当细胞分裂时，每个新生细胞都必须获得完整的DNA拷贝。为了确保这种情况发生，细胞分裂必须严格控制。目前尚不清楚这在细菌中是如何发生的。然而，如果我们知道这种控制涉及哪些分子，我们就可以靶向它们来杀死有害细菌。该项目旨在确定这些调控分子作为抗菌剂的候选靶标，以期开发强大的新型抗生素，以保护我们免受生物恐怖主义和耐药细菌的迫在眉睫的威胁。

When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a view to developing powerful, novel antibiotics to protect us from the imminent threat of bioterrorism and antibiotic-resistant bacteria.