Bacterial Proteomics: From Cell Division to Novel Antibiotic Targets

细菌蛋白质组学：从细胞分裂到新型抗生素靶点

• 批准号: LP0349118
• 负责人: Prof Elizabeth Harry
• 金额: $ 43.16万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-04-29 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0349118
• 关键词: Bacterial; Proteomics; Cell; Division; Novel

When a cell divides it is essential that each newborn cell gets a complete copy of the DNA. To ensure that this happens, cell division must be tightly controlled. It is not known how this occurs in bacteria. However, if we knew what molecules were involved in this control, we could target them to kill harmful bacteria. This project aims to identify such regulatory molecules as candidate targets for antimicrobial agents, with a view to developing powerful, novel antibiotics to protect us from the imminent threat of bioterrorism and antibiotic-resistant bacteria.

当细胞分裂时，每个新生细胞都必须获得完整的DNA拷贝。为了确保这一点发生，细胞分裂必须得到严格控制。目前还不知道这种情况是如何在细菌中发生的。然而，如果我们知道这种控制涉及哪些分子，我们就可以针对它们来杀死有害细菌。该项目旨在将此类调控分子确定为抗菌剂的候选靶标，以期开发强大的新型抗生素，以保护我们免受生物恐怖主义和抗药性细菌的迫在眉睫的威胁。