Regulatory mechanism of hesperidin, a citrus flavonoid, in bone metabolism and prevention of osteoporosis

点击翻译按钮获取中文摘要

Among the naturally occurring citrus flavonoids, hesperidin, a flavanon glycoside, also regulates hepatic cholesterol synthesis by inhibiting the activity of 3-hydroxy-3-methylglutanyl coenzyme A (HMG-CoA) reductase. On the other hand, Mundy et al. reported that statins, cholesterol lowering agents, induce bone formation and inhibit bone resorption both in vitro and in vivo. I examined the effects of hesperidin on bone metabolism in ovariectomized mice, animal models of osteoporosis. The results of my experiment suggest that hesperidin may act on bone by the same mechanism as that of statins, and hesperidin effects on bone metabolism which inhibit activation of Rho-A by mevalonate-GG-PP metabolic pathways.