Effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis

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The purpose of this study was to examine effect of hesperidin on bone metabolism and the elucidation of its mechanism, through mevalonate synthesis. The concomitant intake of glucosylhesperidin and mevalonic acid had better effects in femur bone mineral density (BMD) and bone quality than glucosylhesperidin alone in ovariectomized mice. Hesperetin inhibited the osteoclast formation induced by RANKL in a dose-dependent manner in RAW 264 cells. These results indicate that hesperidin regulates the downstream signaling pathway of cholesterol synthesis, and the inhibition of bone resorption may contribute to the improvement bone metabolism.