Self-assembly of DNA-functionalized hydrogel microstructure

我们发展了一种在超重力离心下合成水凝胶微结构的简单方法。利用这种方法，我们实现了（1）保持水凝胶微结构的表面，可以直接用功能分子修饰，（2）通过多管毛细管产生各向异性和多室化的水凝胶微结构，（3）通过同时封装磁性纳米珠和活细胞来功能化水凝胶微结构，和（4）通过施加外部磁场自组装磁活性水凝胶微结构。

We developed a simple synthesis method of hydrogel micro-structures under ultra-high gravity created by a centrifuge. Using this method, we achieved(1) keepingthe surface of hydrogel micro-structures that can be directly modified with functional molecules,(2) creating anisotropic and multi-compartmentalized hydrogelmicro-structures by using multi-barreled capillary,(3) functionalizing the hydrogelmicro-structures by encapsulating both magnetic nanobeads and living cellsat thesame time, and(4) self-assembling the magnetic-active hydrogel micro-structuresby applying an external magnetic field.