Molelucar Biological Analysis for the mechanism of the hind limb formation of the dolphin with fin-shaped hind limbs

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In order to elucidate the genetic mechanism of the hind limb formation of the unique female bottlenose dolphin (Tursiops truncatus) with fin-shaped hind limbs, we performed genome analysis of the dolphin using a next generation sequencer. We found a missense mutation in a homeobox gene, which is known to regulate development and formation of the hind limbs in mammals, therefore the gene is a strong candidate responsible for the hind limb formation in the dolphin. For the DNA source and future developmental biological experiments of her genome, we are trying to establish her immortal cell lines and iPS cells by recombinant viruses