Benetzung mit Polymer-Lipid-Verbundmembranen und Funktionalisierung von Festkörpern

这个项目的主要目标是锚定亲水性多糖(C.F.，葡聚糖，透明质酸，壳聚糖等)。在均质和横向图案化的“毛棒”聚合物的Langmuir-Blodgett(LB)膜的功能表面。聚合物膜(以及聚合物/脂类复合材料后期)的溶胀行为主要是用最近发展起来的成像微椭圆偏振光谱仪在受控湿度条件下进行研究的。作为‘功能平台’的‘毛棒’LB膜可以(I)将各种生物聚合物(受体、酶)共价锚定在表面上，(Ii)控制膜厚度以优化椭偏仪对比度，(Iii)通过光刻形成聚合物膜的结构，以及(Iv)通过光化学技术官能化。通过反射干涉对比显微镜(RICM)监测囊泡在结构表面上的附着。主要的科学目标是：(1)通过测量作为水的化学势的函数的膜厚度来估计各种生物聚合物在毛棒上的分子间势(2)研究接触角、润湿液滴的形状和功能模式上的滞后(3)作为细胞-组织相互作用的模型测量脂膜(单层、双层和囊泡)在结构聚合物膜上的附着

The primary goal of this project is to anchor hydrophilic polysaccharides (c.f., dextran, hyaluronic acid, chitosan, etc.) onto homogeneous and laterally patterned functional surfaces of Langmuir-Blodgett (LB) films of 'hairy-rod' polymers. The swelling behavior of the polymer films (and of polymer / lipid composite in a later stage) is mainly studied by a recently developed imaging microellipsometry under controlled humidity conditions.The 'hairy-rod' LB films as 'functional platforms' enable (i) covalent anchoring of various biopolymers (receptors, enzymes) onto the surfaces, (ii) control of film thickness to optimize ellipsometric contrast, (iii) structuring of polymer films by photolithography, and (iv) functionalization by photochemical techniques. Adhesion of vesicles onto the structured surfaces is monitored by the reflection interference contrast microscopy (RICM)Main scientific goals are:(1) Estimation of intermolecular potentials of various biopolymers grafted onto 'hairy-rods' by measuring film thicknesses as a function of the chemical potential of H2O(2) Study of contact angles, shape of wetting droplets, and hysteresis on functional patterns(3) Measurement of adhension of lipid films (monolayer, bilayer, and vesicles) on structured polymer films as a model of cell-tissue interaction