Benetzung mit Polymer-Lipid-Verbundmembranen und Funktionalisierung von Festkörpern

聚合物-脂质复合膜润湿和固体功能化

• 批准号: 5107186
• 负责人: Professor Dr. Motomu Tanaka
• 金额: --
• 依托单位: Physikalisch-Chemisches Institut
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 1998
• 资助国家: 德国
• 起止时间: 1997-12-31 至 2004-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5107186?language=en
• 关键词: Benetzung; mit; Polymer; Lipid; Verbundmembranen

The primary goal of this project is to anchor hydrophilic polysaccharides (c.f., dextran, hyaluronic acid, chitosan, etc.) onto homogeneous and laterally patterned functional surfaces of Langmuir-Blodgett (LB) films of 'hairy-rod' polymers. The swelling behavior of the polymer films (and of polymer / lipid composite in a later stage) is mainly studied by a recently developed imaging microellipsometry under controlled humidity conditions.The 'hairy-rod' LB films as 'functional platforms' enable (i) covalent anchoring of various biopolymers (receptors, enzymes) onto the surfaces, (ii) control of film thickness to optimize ellipsometric contrast, (iii) structuring of polymer films by photolithography, and (iv) functionalization by photochemical techniques. Adhesion of vesicles onto the structured surfaces is monitored by the reflection interference contrast microscopy (RICM)Main scientific goals are:(1) Estimation of intermolecular potentials of various biopolymers grafted onto 'hairy-rods' by measuring film thicknesses as a function of the chemical potential of H2O(2) Study of contact angles, shape of wetting droplets, and hysteresis on functional patterns(3) Measurement of adhension of lipid films (monolayer, bilayer, and vesicles) on structured polymer films as a model of cell-tissue interaction

该项目的主要目标是锚亲水性多糖（参见，葡聚糖、透明质酸、壳聚糖等）在“毛棒”聚合物的LB膜的均匀和横向图案化的功能表面上。聚合物膜的溶胀行为在控制湿度的条件下，用显微椭圆偏振成像技术研究了聚合物/脂质复合物的表面形貌和结构。“毛杆”LB膜作为“功能平台”，使（i）各种生物聚合物的共价锚定成为可能（ii）控制膜厚度以优化椭圆偏振对比度，（iii）通过光刻法构造聚合物膜，和（iv）通过光化学技术官能化。囊泡在结构化表面上的粘附通过反射干涉衬度显微镜（RICM）监测。主要科学目标是：（1）通过测量膜厚度作为H2O化学势的函数来估计接枝到“毛状杆”上的各种生物聚合物的分子间势（2）研究接触角、润湿液滴形状和功能图案的滞后（3）测量脂质膜（单层、双层和囊泡）在结构化聚合物膜上的粘附，作为细胞-组织相互作用的模型