Genetic variation of transcriptional control

转录控制的遗传变异

• 批准号: DP0453243
• 负责人: Prof Peter Little
• 金额: $ 15.67万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0453243
• 关键词: Genetic; variation; transcriptional; control

Genetic variation is a key cause phenotype differences in humans, animals, and plants and so of great economic importance. Despite its proven importance to human diseases, ?quantitative? variation in the amount of gene expression rather than ?qualitative? protein sequence changes, has not been systematically studied. We have developed a powerful method to identify genetic causes of quantitative variation using crosses of inbred mice in conjunction with microarray techniques to analyse expression of thousands of genes simultaneously. These studies will be extended to humans and be significant to wide areas of biological and commercial activity.

遗传变异是人类、动物和植物表型差异的关键原因，因此具有重要的经济意义。尽管它已被证明对人类疾病很重要，但定量的？基因表达量的变化而不是“质”的变化。蛋白质序列的变化，尚未得到系统的研究。我们已经开发了一种强大的方法来识别定量变异的遗传原因，使用近交系小鼠的杂交结合微阵列技术来同时分析数千个基因的表达。这些研究将扩展到人类，并对生物和商业活动的广泛领域具有重要意义。