KIT as a target for the modification of vascular proteoglycans and prevention of atherosclerosis

KIT作为血管蛋白多糖修饰和预防动脉粥样硬化的靶点

• 批准号: nhmrc : 472611
• 负责人: Prof Peter Little
• 金额: $ 22.86万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/kit-target-modification-prevention-atherosclerosis/94459
• 关键词: KIT; target; modification; vascular; proteoglycans

Heart disease occurs when arteries supplying blood to the heart become blocked. One aspect of this blockage is the capture of fats from the blood, by artery wall structures called proteoglycans. Proteoglycans are made up of a core protein and sugar chains (GAGs). The stickier the GAGs, the more fats that are captured. No drug treatment acts directly on the artery wall to prevent heart disease. This project aims to identify steps that lead to stickier GAGs and therefore a potential drug target.

当供应心脏血液的动脉受阻时，就会发生心脏病。这种堵塞的一个方面是被称为蛋白多糖的动脉壁结构从血液中捕获脂肪。蛋白多糖由核心蛋白质和糖链(GAG)组成。口香糖越粘，捕获的脂肪就越多。没有药物治疗直接作用于动脉壁来预防心脏病。该项目旨在确定导致更粘性口香糖的步骤，从而成为潜在的药物靶点。