Impact of microbiota-brain communication on MS-related autoimmunity

微生物群-大脑通讯对多发性硬化症相关自身免疫的影响

• 批准号: 516180294
• 负责人: Professorin Dr. Claudia Günther
• 金额: --
• 依托单位: Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516180294?language=en
• 关键词: Impact; microbiota; brain; communication; MS

Multiple sclerosis (MS) is the most common chronic inflammatory autoimmune disease of the central nervous system (CNS) and starts in young individuals in the most productive period of their lives. Its multifactorial pathogenesis includes genetic and environmental factors such as communication of the gut microbiota with peripheral and central immune processes. Accordingly, previous studies have demonstrated that commensal microorganism in the gut can modulate immunological processes both in the peripheral immune system as well as within the CNS and alterations in gut microbial composition have been identified as essential component of neuroinflammation. In this context, published and preliminary data from our groups suggest that microbial derived factors participate in the onset and progression of autoimmune CNS inflammation in MS. However, our mechanistic understanding of these processes is still limited. Within this project, we will dissect microbiota-gut-brain communication via bacterial-derived extracellular vesicles and determine how this interaction affects the CNS and MS related autoimmunity. The long-term vision of this project is to identify novel routes of microbiota-brain crosstalk that can be targeted for therapeutic approaches.

多发性硬化症（MS）是中枢神经系统（CNS）最常见的慢性炎症性自身免疫性疾病，并且开始于年轻个体生命中最具生产力的时期。其多因素发病机制包括遗传和环境因素，如肠道微生物群与外周和中枢免疫过程的沟通。因此，先前的研究已经证明，肠道中的肠道微生物可以调节外周免疫系统以及CNS中的免疫过程，并且肠道微生物组成的改变已经被鉴定为神经炎症的重要组成部分。在这种情况下，从我们的小组公布的和初步的数据表明，微生物源性因子参与MS的自身免疫性CNS炎症的发病和进展。然而，我们对这些过程的机制的理解仍然是有限的。在这个项目中，我们将通过细菌衍生的细胞外囊泡解剖微生物群-肠-脑通信，并确定这种相互作用如何影响CNS和MS相关的自身免疫。该项目的长期愿景是确定可用于治疗方法的微生物-大脑串扰的新途径。