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Control and physiology of totally replaced turbo artificial heart

全置换涡轮人工心脏的控制与生理学

基本信息

批准号：
09470282
负责人：
ARAKI Kenji
金额：
$ 7.87万
依托单位：
Miyazaki Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Detection and implications of the characteristic points for estimating the assisting condition in a continuous-flow artificial heart -In vitro study-In this study, we used a specially devised mock circuit consisting of a sac-type pulsatile pump, three reservoirs, and our mixed flow pump (MFP) as a CFAH. The motor current waveform was monitored. The pump speed of the MFP was changed from 2000 rpm to 5000 rpm, We calculated the index of motor current amplitude (ICA), which was obtained, by dividing the amplitude of the motor current by the simultaneous mean value. The ICA plotted against the pump speed (ICA-pump speed relationship) showed several characteristic points: the t-i point, the PR0.7 point, the PR0.5 point, and the maxQ point. The t-i points strongly corresponded to the tuning point from partial to total left heart assistance. When the contractility, afterload, and preload were changed, the pump flow rate at each point changed, depending on the preload like Starling's law. Thes … More e data suggest that the assisting status of a CFAH could be estimated by detecting the characteristic points of the ICA-pump speed relationship,Investigation of the methods of controlling the Biventricular Assist Device with continuous flow pumps.Using 5 piglets, we set a BVAD with continuous flow pumps via left thoracotomy. Global ischemia was induced for 30 minutes by clamping the base of the ascending aorta. After unclamping the aorta, the analysis of pumping performance was evaluated every an hour for over 6 hours reperfusion. To detect ventricular collapse without any specific sensor, we calculated the index of current amplitude (ICA) from motor current waveforms and simultaneous mean current values, and applied these data when controlling the BVAD. The RVAD speed was determined by setting the target LVAD flow and target ICA value. Using the LVAD target ICA value, we could set the RVAD flow rate to match cardiac function. Using the known pump flow or the pump-flow estimation can be one method of controlling BVAD with continuous flow pumps. Less

用于估计连续流动人工心脏辅助条件的特征点的检测和影响 -体外研究 - 在这项研究中，我们使用了专门设计的模拟电路，该模拟电路由囊型脉动泵、三个储液器和我们的混流泵（MFP）组成作为 CFAH。监测电机电流波形。 MFP 的泵速从 2000 rpm 变为 5000 rpm，我们通过将电机电流幅值除以同时平均值来计算电机电流幅值指数 (ICA)。根据泵速绘制的 ICA（ICA-泵速关系）显示了几个特征点：t-i 点、PR0.7 点、PR0.5 点和 maxQ 点。 t-i 点与从部分左心辅助到全部左心辅助的调整点密切对应。当收缩性、后负荷和预负荷改变时，每个点的泵流量都会改变，这取决于预负荷，就像斯塔林定律一样。这些数据表明，可以通过检测ICA-泵速关系的特征点来估计CFAH的辅助状态，研究连续流泵双心室辅助装置的控制方法。我们以5头仔猪为对象，通过左开胸设置连续流泵BVAD。通过夹住升主动脉基部诱导全身缺血30分钟。松开主动脉后，在再灌注超过 6 小时的时间内，每小时评估一次泵血性能分析。为了在没有任何特定传感器的情况下检测心室塌陷，我们根据运动电流波形和同时平均电流值计算了电流幅度指数 (ICA)，并在控制 BVAD 时应用这些数据。通过设置目标 LVAD 流量和目标 ICA 值来确定 RVAD 速度。使用 LVAD 目标 ICA 值，我们可以设置 RVAD 流速以匹配心脏功能。使用已知的泵流量或泵流量估计可以是控制连续流泵的 BVAD 的一种方法。较少的