Pulpal inflammation alters the physiological properties of intradental nerves in the adjacent teeth

牙髓炎症改变邻牙牙内神经的生理特性

• 批准号: 09470421
• 负责人: KAWASHIMA Nobuyuki
• 金额: $ 6.02万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470421/
• 关键词: Dental Pulp; Pulpal Blood Flow; Pulpal Nerve; Branched Nerve Fiber; Mustard Oil; Axon Reflex; Cat; Laser Doppler Flowmeter; 歯髄神経; 分岐歯髄神経; 神経原性炎症

Stimulation of the tooth crown induces vasodilation in the tooth pulp. This vasodilation seems to be mediated by the release of neuropeptides from the terminals of activated fine caliber afferent fibers. It has been suggested that the vasodilator response in the pulp spread as an axon reflex along the peripheral nerve branches when the tooth pulp is stimulated. On the other hand, branched dental nerves supplying the pulps of multiple teeth have been identified by electrophysiological and anatomical studies.The aims of this study were to investigate whether pulpal blood flow changes and intradental nerve activity can be induced by stimulation of an adjacent tooth to confirm the existence of branched afferents innervating both tooth pulps.Mustard oil or mechanical stimulation was applied to maxillary second premolar tooth pulps and pulpal blood flow and/or intradental nerve activity in the ipsilateral canine tooth were recorded in the cat. Mustard oil application to the second premolar p … More ulp significantly increased blood flow in the canine tooth. Sectioning of the infraorbital nerve and its branches on the experimental side did not affect this pulpal blood flow increase. The paraperiosteal injection of lidocaine without vasoconstrictor significantly inhibited the canine pulpal blood flow increase induced by mustard oil application to the second premolar pulp. Sporadic firing or sometimes bursts of action potentials in the canine pulp nerves were recorded during and/or after the mustard oil application to the second premolar pulp in some cases. Single pulp nerve units firing in synchrony with the mechanical stimulation of the second premolar pulp were recorded in some canines, which substantiated the existence of branched afferents innervating both teeth. These findings suggest that stimulation of the second premolar pulp may induce axon reflex-related vasodilation and intradental nerve firing in the canine pulp via branched afferent fibres innervating both the second premolar and canine teeth. Less

刺激牙冠会引起牙髓血管舒张。这种血管舒张似乎是由激活的细口径传入纤维末端释放神经肽介导的。有人提出，当牙髓受到刺激时，牙髓中的血管舒张反应作为轴突反射沿着周围神经分支传播。另一方面，通过电生理学和解剖学研究已经鉴定出供应多颗牙齿牙髓的分支牙神经。本研究的目的是探讨刺激相邻牙齿是否可以引起牙髓血流变化和牙内神经活动，以确认支配两颗牙髓的分支传入神经的存在。对上颌第二前磨牙牙髓和牙髓血施加芥末油或机械刺激 记录猫同侧犬齿的血流和/或牙内神经活动。将芥末油涂抹在第二前磨牙上可显着增加犬齿的血流量。实验侧眶下神经及其分支的切断并不影响牙髓血流量的增加。骨膜旁注射不加血管收缩剂的利多卡因显着抑制了芥子油涂抹到第二前磨牙牙髓引起的犬牙髓血流增加。在某些情况下，在将芥子油施加到第二前磨牙牙髓期间和/或之后，记录了犬牙髓神经中的零星放电或有时爆发的动作电位。在一些犬齿中记录到与第二前磨牙牙髓的机械刺激同步放电的单个牙髓神经单元，这证实了支配两颗牙齿的分支传入神经的存在。这些发现表明，刺激第二前磨牙牙髓可能会通过支配第二前磨牙和犬齿的分支传入纤维，诱导轴突反射相关的血管舒张和犬牙髓中的牙内神经放电。较少的

项目成果

引地朱美ら: "ネコ犬歯歯髄血流と歯髄内神経活動に対する前臼歯歯髄刺激の影響"口腔病学会誌. 66. 415 (1999)

Akemi Hikichi 等人：“前磨牙牙髓刺激对猫牙髓血流和牙髓内神经活动的影响”口腔医学会杂志 66. 415 (1999)。

山本寛ら: "痛みの臨床各論 歯と歯根膜の痛み"医歯薬出版. 305 (1997)

Hiroshi Yamamoto 等：“疼痛的临床理论：牙齿和牙周韧带疼痛”Ishiyaku Publishing 305 (1997)。

山本 寛ら: "痛みの臨床各論 歯と歯根膜の痛み"医歯薬出版. 305 (1997)

Hiroshi Yamamoto 等：“疼痛的临床理论：牙齿和牙周韧带疼痛”Ishiyaku Publishing 305 (1997)。

H.Yamamoto et al: "Srimulation Applied to a Tooth Affects the Intradental Nerve Activity of Another Tooth" J Dent Res. 76 Special Issue. 301- (1997)

H.Yamamoto 等人：“应用于一颗牙齿的刺激会影响另一颗牙齿的牙内神经活动”J Dent Res。

M.Sunakawa et al.: "Jaw electromyographic activity induced by the application of algesic chemicals to the rat tooth pulp"Pain. 80(3). 493-501 (1999)

M.Sunakawa 等人：“对大鼠牙髓应用止痛化学物质诱发下颌肌电活动”疼痛。