Effects of Notch Signaling on the Pulpal Cell Differentiation and the Horizon of Pulpal Regeneration by Regulation of Notch Signaling

Notch 信号传导对牙髓细胞分化的影响以及通过调节 Notch 信号传导实现牙髓再生的范围

• 批准号: 19390481
• 负责人: KAWASHIMA Nobuyuki
• 金额: $ 10.57万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390481/
• 关键词: 歯髄細胞; 象牙芽細胞; 分化; Notch; 未分化間葉系細胞; Hey1; Notchシグナル; 歯髄細胞分化; 歯髄再生; 歯髄; 石灰化; 歯胚

A numerous factors are involved in the course of odontoblastic differentiation. We revealed the importance of Notch signaling in the osteoblastic differentiation, suggesting that the Notch signaling may one of the essential factors to regulate the differentiation of mesenchymal stromal cells into hard tissue forming cells. In the pulp cells, Notch signaling took a central role of odontoblastic differentiation, and active Notch signaling induced pulp cells remained undifferentiated. Hey1 was a major transcriptional factor in the Notch signaling in the osteo/odonto-blastic differentiation, and enforced expression of Hey1 in the pulp cells were disturbed their odontoblastic differentiation.

成牙本质细胞分化过程中涉及多种因素。我们揭示了Notch信号在成骨细胞分化中的重要性，提示Notch信号可能是调控间充质基质细胞向硬组织形成细胞分化的重要因素之一。在牙髓细胞中，Notch信号在成牙本质细胞分化中起中心作用，而激活的Notch信号诱导的牙髓细胞仍未分化。Hey1是成骨/成牙本质细胞分化过程中Notch信号转导途径中的主要转录因子，其在牙髓细胞中的表达受其成牙本质细胞分化的干扰。

项目成果

歯髄細胞におけるOsterix発現

牙髓细胞中的 Osterix 表达

• 发表时间: 2009
• 作者: 川島伸之;許セイ;周夢宇;瀧本晃陽;小泉悠;大井知恵;高橋里美;鈴木則元;須田英明
• 通讯作者: 須田英明

Essential Endodontology

基础牙髓病学

• 发表时间: 2007
• 作者: Kawashima N;Suda H
• 通讯作者: Suda H

Notch Signaling in the Dental Pulp

牙髓中的缺口信号传导

• 发表时间: 2008
• 作者: N. KAWASHIMA;S. TAKAHASHI;S. OKUHARA;C. OHI;H. SUN;H. WANG;J. XU;K. -I. KATSUBE;S. ARANY;A. NAKATA;T. SUGIYAMA;H. SUDA
• 通讯作者: H. SUDA

Role of Mef2c signaling in osteoblast differentiation.

Mef2c 信号在成骨细胞分化中的作用。

• 发表时间: 2008
• 作者: N. Kawashima;S. Takahashi;J. Xu;S. Okuhara;H. Wang;C. Ohi;N. Suzuki;H. Suda
• 通讯作者: H. Suda

Essential Endodontology(Orstavik D and Pitt Ford TR editors, Pathological aspects of pulpal and periapical inflammations)

基本牙髓病学（Orstavik D 和 Pitt Ford TR 编辑，牙髓和根尖周炎症的病理学方面）

• 发表时间: 2007
• 作者: Kawashima N;Suda H
• 通讯作者: Suda H