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Analysis of 3-D cultured dental pulp cells and osteoblasts and their clinical application

Analysis of 3-D cultured dental pulp cells and osteoblasts and their clinical application
3D培养牙髓细胞和成骨细胞分析及其临床应用
批准号：
22659343
负责人：
KAWASHIMA Nobuyuki
金额：
$2.07万
依托单位：
Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659343/
关键词：
歯髄細胞骨芽細胞象牙芽細胞細胞分化硬組織形成三次元培養二次元培養分化石灰化低酸素未分化遺伝子発現解析初代培養成長因子臨床応用

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中文摘要
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英文摘要
Dental pulp cells are differentiate into odontoblasts, which are dentin-forming cells, and osteoblasts are bone tissue-forming cells. These cells are categorized as hard tissue forming cells, and may possess common properties. Mineralization of these cells in the conventional two dimensional culture is only observed in the presence of mineralization-inducing factors, such as BMPs or ascorbic acid and beta-glycerophosphate. We revealed that three dimensional (3-D) culture induced up-regulation of odonto-/osteo-blast marker expression in dental pulp cells and osteoblasts. Transplantation of 3-D cultured pulp cells or osteoblasts into bone cavities effectively induced hard tissue formation. Clinical application of 3-D cultured dental pulp cells or osteoblasts are expected.
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会议论文
歯髄幹細胞と再生医療
牙髓干细胞与再生医学
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [丸濵功太郎, 松香芳三, 寺山隆司, 窪木拓男, 杉本朋貞, 福安 翔,江草 宏,萱島浩輝,裏口真也,鎌野優弥,佐伯万騎男,矢谷博文, 川島伸之]
通讯作者： 川島伸之
Promotional effects of vasoactive intestinal peptide on the development of rodent Hertwig’s epithelial root sheath
血管活性肠肽对啮齿动物Hertwig上皮根鞘发育的促进作用
DOI： 10.1111/j.1741-4520.2012.00371.x
发表时间： 2012
期刊： Congenital Anomalies
影响因子： 1.3
作者： [J Xu, N Kawashima, N Fujiwara, H Harada, MS. Ota, H Suda]
通讯作者： H Suda
Effects of MMP-3 on Inflammatory Mediator Synthesis from Macrophages
MMP-3 对巨噬细胞合成炎症介质的影响
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [K Takimoto, N Kawashima, M Nakashima, H Nakamura, Y Koizumi, H Suda]
通讯作者： H Suda
Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor
哺乳动物转录阻遏蛋白促进小鼠间充质祖细胞 Kusa-A1 成骨分化
DOI： --
发表时间： 2010
期刊： Rbpj Biochemical and Biophysical Research Communications
影响因子： --
作者： [S. Wang, N. Kawashima, K. Sakamoto, K. Katsube, A. Umezawa, H Suda]
通讯作者： H Suda
共 34 条
    Control of pulpal inflammation and hard tissue regeneration by miR-21, a modulator of cross-talk between inflammation and tissue regeneration
    • 批准号：
      16K15795
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.16万
    • 财政年份：
      2016
    • 负责人：
      KAWASHIMA Nobuyuki
    • 依托单位：
      Tokyo Medical and Dental University
    Establishment of dental pulp stem cell-isolation method and clinical approach of dental pulp tissue regeneration using dental pulp stem cells by signaling network control
    • 批准号：
      25293386
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.98万
    • 财政年份：
      2013
    • 负责人：
      KAWASHIMA Nobuyuki
    • 依托单位：
      Tokyo Medical and Dental University
    Resolution of the signaling networks involved in the pulp cell differentiation and its clinical application
    • 批准号：
      22390357
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.82万
    • 财政年份：
      2010
    • 负责人：
      KAWASHIMA Nobuyuki
    • 依托单位：
      Tokyo Medical and Dental University
    Effects of Notch Signaling on the Pulpal Cell Differentiation and the Horizon of Pulpal Regeneration by Regulation of Notch Signaling
    • 批准号：
      19390481
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $10.57万
    • 财政年份：
      2007
    • 负责人：
      KAWASHIMA Nobuyuki
    • 依托单位：
      Tokyo Medical and Dental University
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