Resolution of the signaling networks involved in the pulp cell differentiation and its clinical application

牙髓细胞分化相关信号网络的解析及其临床应用

• 批准号: 22390357
• 负责人: KAWASHIMA Nobuyuki
• 金额: $ 10.82万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390357/
• 关键词: 歯髄; 歯髄細胞; 象牙芽細胞; Notch; Periostin; 細胞分化; シグナルネットワーク; 分化制御; 分化促進; 転写調節因子; 分化誘導; Hey1; 分化; 石灰化; Sp7

Losing the tooth vitality correlates to the tooth loss, this is a challenge to QOL. Strategies to keep the integrity of the pulp tissue and regenerate the new pulp tissue are hot topics. We have reported that Notch signaling is essential for differentiation of dental pulp cells. In this project, we revealed that a secretory protein, Periostin, regulated negatively the dental pulp cell differentiation into odontoblasts via notch signaling. Controlling the synthesis and production Periostin may be essential to induce the non-mineralized pulp tissue covered by the newly formed mineralized dentin.

牙齿活力丧失与牙齿脱落密切相关，这对生活质量是一个挑战。如何保持牙髓组织的完整性和再生新的牙髓组织是目前研究的热点。我们已经报道了Notch信号在牙髓细胞分化中的重要作用。在本项目中，我们发现分泌蛋白Periostin通过notch信号负调控牙髓细胞向成牙本质细胞分化。控制Periostin的合成和产生可能是诱导新形成的矿化牙本质覆盖非矿化牙髓组织的必要条件。

项目成果

Kinetics of Th17-related cytokine expression in experimentally induced rat periapical lesions

实验诱导的大鼠根尖周病变中 Th17 相关细胞因子表达的动力学

• DOI: 10.1111/j.1747-4477.2012.00371.x
• 发表时间: 2012
• 期刊: Aust Endod J
• 影响因子: 1.6
• 作者: S Wei;N Kawashima;N Suzuki;J Xu;S Takahashi;M Zhou;Y Koizumi;H Suda
• 通讯作者: H Suda

単層培養法と三次元培養法における歯髄細胞の象牙芽細胞分化について

关于单层培养法和三维培养法中牙髓细胞的成牙本质细胞分化

• 发表时间: 2011
• 作者: 山本弥生子;川島伸之;須田英明
• 通讯作者: 須田英明

Mineralization of Odonotoblastic-Lineage Cells Was Accelerated by Enhanced Expression of Mef2c

Mef2c 表达的增强加速了成牙本质细胞谱系细胞的矿化

• 发表时间: 2011
• 作者: N Kawashima;J Xu;N Suzuki;M Zhou;K Takimoto;Y Koizumi;M Yamamoto;S Takahashi;T Sugiyama;H Suda
• 通讯作者: H Suda

Mechanisms of Bone Destruction in the Periapical Lesions and Its Regulation

根尖周病变骨质破坏机制及其调控

• 发表时间: 2011
• 作者: Kawashima N;Suzuki N;Suda H
• 通讯作者: Suda H

Effects of Dentin Surface Modifications Treated with Er:YAG and Nd:YAG Laser Irradiation on Fibroblast Cell Adhesion

• DOI: 10.1089/pho.2011.3132
• 发表时间: 2012-02-01
• 期刊: PHOTOMEDICINE AND LASER SURGERY
• 作者: Bolortuya, Gombo;Ebihara, Arata;Suda, Hideaki
• 通讯作者: Suda, Hideaki