Dynamics and Steering of Superparamagnetic Nanoparticles in Simple and Branched Vessels: Simulation & Experiment (DyNano)

简单和分支容器中超顺磁性纳米颗粒的动力学和转向：模拟

• 批准号: 518492286
• 负责人: Professor Dr. Eberhard Bänsch
• 金额: --
• 依托单位: Lehrstuhl für Angewandte Mathematik III
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/518492286?language=en
• 关键词: Dynamics; Steering; Superparamagnetic; Nanoparticles; Simple

Magnetic drug targeting (MDT) using superparamagnetic iron oxide nanoparticles (SPIONs) is an effective method for increasing drug delivery to tumour tissue in cancer therapy, thereby reducing the total amount of drug and the side effects associated with the therapy. While the efficacy of the approach has already been proven in studies, approaches to adapt and optimise this method to the individual case are still lacking. Therefore, the aim of this application is to lay the foundations for such patient-specific optimisation: Comparable to the procedure already successfully practised in radiotherapy, the magnetic fields for MDT shall be optimised in future on the basis of the patient's vascular structure and the characteristics of the tumour: The proportion of the pharmaceutical that reaches the tumour tissue shall be maximised. To this end, a physiological-physical model of the movement and magnetic field-based steering of SPIONs shall be developed, implemented as a Finite-element model and experimentally validated in the proposed project. This model shall allow to optimise the time-variable field strength and position of one or more electromagnets with regard to the particle concentration in a target area. Within the project, the steering in channel systems with single and multiple branchings as well as at the transition from the vessel into the surrounding tissue will be investigated. This will provide the basis for transferring the optimisation approach to given vascular and tumour models in clinical application in future. The mathematical-algorithmic development of the simulation and optimisation tool is the responsibility of the Chair of Applied Mathematics III (AM3) at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU). Throughout the course of the project, this model will be validated and extended on the basis of experiments. The associated experimental setups will be developed jointly by the Institute of Electronics Engineering (LTE) of FAU and the Section for Experimental Oncology and Nanomedicine (SEON) of University Hospital Erlangen. LTE is responsible for the measurement of SPION concentration and for the particle steering setup, SEON for the nanoparticles and the vascular models including experiments on human umbilical arteries.

利用超顺磁性氧化铁纳米颗粒(SPION)的磁性药物靶向(MDT)是一种在肿瘤治疗中增加药物向肿瘤组织输送的有效方法，从而减少药物的总量和与治疗相关的副作用。虽然这种方法的有效性已经在研究中得到了证明，但仍然缺乏适应和优化这种方法以适应个别情况的方法。因此，这项应用的目的是为这种针对患者的优化奠定基础：与已经在放射治疗中成功实施的程序相比，未来将根据患者的血管结构和肿瘤的特征来优化MDT的磁场：应最大限度地增加到达肿瘤组织的药物比例。为此，将开发SPION的运动和基于磁场的转向的生理物理模型，并将其实现为有限元模型，并在拟议的项目中进行实验验证。该模型应允许根据目标区域中的粒子浓度来优化一个或多个电磁铁的时变场强和位置。在该项目中，将研究具有单分支和多分支的通道系统中的转向以及从血管到周围组织的过渡。这将为将优化方法转移到给定的血管和肿瘤模型在未来的临床应用提供基础。模拟和优化工具的数学算法开发是弗里德里希-亚历山大-纽伦堡大学(FAU)应用数学III(AM3)主席的责任。在整个项目过程中，将在实验的基础上对该模型进行验证和推广。相关的实验装置将由FAU电子工程研究所(LTE)和Erlangen大学医院实验肿瘤学和纳米医学部(SEON)联合开发。LTE负责SPION浓度的测量和粒子转向装置、纳米粒子的扫描和血管模型，包括在人脐动脉上的实验。