Cell-fate decision upon RNA sensing by RIG-I like receptors and viral restriction factors (A28*)

RIG-I 样受体和病毒限制因子对 RNA 感应的细胞命运决定 (A28*)

• 批准号: 518802919
• 金额: --
• 依托单位: Abteilung für Klinische Pharmakologie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/518802919?language=en
• 关键词: Cell; fate; decision; upon; RNA

We have recently demonstrated that RIG-I and OAS1 share ligand requirements regarding short dsRNAs with a 5’-triphosphate moiety. Both receptor systems influence the cell fate with RIG-I activation leading to type I IFN secretion and induction of an antiviral cellular state and OAS1/RNase L inhibiting viral replication via translational inhibition and ultimately cellular demise. We will decipher the molecular activation requirements of OAS1 and analyse how the intricate interplay of downstream events upon RIG-I and OAS1 and other viral restriction factors shape the cell fate and immunogenicity of the RNA sensing event in order to induce an effective antiviral immune response.

我们最近已经证明，RIG-I和OAS 1共享关于具有5 '-三磷酸部分的短dsRNA的配体要求。两种受体系统都影响细胞命运，RIG-I活化导致I型IFN分泌和诱导抗病毒细胞状态，OAS 1/RNase L通过翻译抑制和最终细胞死亡抑制病毒复制。我们将破译OAS 1的分子活化要求，并分析下游事件对RIG-I和OAS 1以及其他病毒限制因子的复杂相互作用如何塑造RNA传感事件的细胞命运和免疫原性，以诱导有效的抗病毒免疫应答。