Cell-fate decision upon RNA sensing by RIG-I like receptors and viral restriction factors (A28*)

我们最近证明了rig - 1和OAS1对于具有5 ' -三磷酸部分的短dsrna具有相同的配体要求。这两种受体系统都影响细胞命运，RIG-I激活导致I型IFN分泌并诱导抗病毒细胞状态，OAS1/RNase L通过翻译抑制抑制病毒复制并最终导致细胞死亡。我们将破译OAS1的分子激活需求，并分析下游事件对RIG-I和OAS1以及其他病毒限制因子的复杂相互作用如何塑造RNA传感事件的细胞命运和免疫原性，以诱导有效的抗病毒免疫反应。

We have recently demonstrated that RIG-I and OAS1 share ligand requirements regarding short dsRNAs with a 5’-triphosphate moiety. Both receptor systems influence the cell fate with RIG-I activation leading to type I IFN secretion and induction of an antiviral cellular state and OAS1/RNase L inhibiting viral replication via translational inhibition and ultimately cellular demise. We will decipher the molecular activation requirements of OAS1 and analyse how the intricate interplay of downstream events upon RIG-I and OAS1 and other viral restriction factors shape the cell fate and immunogenicity of the RNA sensing event in order to induce an effective antiviral immune response.