Studies on experimentally-induced acute hepatic failure

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When heat-killed Propionibacterium acnes (P. acnes) is intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (LPS) is also intravenously injected, most of the mice die of massive necrosis. In this experimentally-induced acute hepatic failure, the adherent cells accumulated into the liver are primed by P. acnes and activated by LPS, producing the cytotoxic factor. This hepatocytotoxic factor is a protein-like substance and is relatively unstable to heat. Furthermore, in this experimentally-induced acute hepatic failure model, gomisin A, AA861, azelastine and prostaglandin <E_1> remarkably increase the survival rate of mice and improve the histological changes and necrosis of the liver cells.