Wound healing-hypertrophic scar and scar contracture

对3只日本猴皮肤的愈合过程和肥大细胞数量的变化进行了研究。在猴大腿皮肤中厚磨削伤处，瘢痕生长迅速，并有一段时间呈现出临床和组织病理学均可描述为增生性瘢痕的特征。增生性瘢痕的炎症和特征很快就消失了，尽管这可能是因为人和猴子的寿命不同。另一方面，据报道，小实验动物，如小鼠，大鼠和兔子，不会产生任何增生性瘢痕。在伤口愈合早期皮肤活检标本中，肥大细胞数量减少，但在接近炎症变化的部位逐渐增多，尤其在炎症后期明显增多，提示瘢痕结缔组织体积的增加与肥大细胞的数量有一定的关系。

The wound-healing process and change of mast cell population were studied in the skin of three Japanese monkeys.In the split-thickness abraded wound of the skin in the monkey thigh, the scar developed quickly and there was a period when it took on features that can be described both clinically and histopathologically as characteristic of hypertrophic scars. The inflammation and features of hypertrophic scar disappeared rapidly, although this may be due to the difference in life span between humans and monkeys.On the other hand, it has been reported that small experimental animals, such as mice, rats and rabbits, do not develop any hypertrophic scars. Therefore, it can be said that the monkey stands between humans and these small experimental animals insofar as the healing process of wound is concerned.In skin biopsy specimens at the early stage of the wound healing, the number of mast cells was found to have decreased, but it increased gradually in the area close to the inflammatory changes and showed a marked increase at the final stage of inflammation in particular.These findings suggest that there is some relationship between the increase in the volume of the connective tissue in scars and the number of mast cells.