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Qualitative and quantitative study of oncogene-products in gliomas.

Qualitative and quantitative study of oncogene-products in gliomas.
神经胶质瘤中癌基因产物的定性和定量研究。
批准号:
60570673
负责人:
TABUCHI Kazuo
金额:
$0.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1985
资助国家:
日本
项目状态:
已结题
起止时间:
1985 至 1987

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中文摘要
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英文摘要
Recent studies showed that the amino acid sequence of epidermal growth factor receptor(EGF-R) was strikingly similar to that of erb B transforming protein, the oncogene product of avian erythroblastosis virus(AEV). On the other hand, EGF-R and pp60^<src>, the product of src oncogene of Rous sarcoma virus(RSV) are believed to share the homologous amino acid sequence in their tyrosine kinase domains. To elucidate possible participation of certain oncogene in the development of glioma, four different human (KY, KH, KC & 118MG) glioma cell lines were examined for the presence of EGF-R,pp60^<src> and p21^<ras> by flow cytometry using specific monoclonal antibodies. It was found that all cell lines tested were positive for either EGF-R or pp60^<src>, or both, but none for p21^<ras>, though the degree of exzpression varied among cell lines. Furthermore, the expression of these oncogene-related products including EGF-R and pp60^<src> in glioma cells was markedly suppressed by such anti-glioma agents as prostaglandin(PG) D_2,J_2 and forskolin which could induce cell differentiation, whereas a very slight increased expression of EGF-R in KY cells was observed after the treatment with H-7, an inhibitor of protein kinase C. These results suggest that the src oncogene family including erb B might be involved in either the development and growth or differentiation of certain glial tumors.
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会议论文
田渕和雄: 神経研究の進歩. 31. 1015-1022 (1987)
田渊一夫:神经研究进展 31. 1015-1022 (1987)。
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通讯作者:
田渕和雄: 第3回 脳腫瘍病理研究会 講演集. 61-69 (1985)
Kazuo Tabuchi:第三届脑肿瘤病理学研究组论文集,61-69 (1985)。
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通讯作者:
田渕和雄: Clinical Neuroscience. 4. 22-25 (1986)
田渊一夫:临床神经科学。4. 22-25 (1986)
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14
    Development of new strategies for cancer treatment based in system biological-analysis of cancer system abnormality
    Biomarker Discovery of CSF biomarker of medulloblastoma by SELDI-TOF mass spectrometry
    • 批准号:
      12470293
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.77万
    • 财政年份:
      2000
    • 负责人:
      TABUCHI Kazuo
    • 依托单位:
    Analysis of apoptosis-related products in delayed neuronal death following cerebral ischemia
    • 批准号:
      10557129
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $4.67万
    • 财政年份:
      1998
    • 负责人:
      TABUCHI Kazuo
    • 依托单位:
    Molecular diagnosis of glioblastomas based on genetic alterations.
    • 批准号:
      09470298
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.64万
    • 财政年份:
      1997
    • 负责人:
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    • 依托单位:
    海外基金