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Ultrasonic noninvasive measurement of elastic properties of arterial wall in atherosclerosis

超声无创测量动脉粥样硬化中动脉壁的弹性特性

基本信息

批准号：
61570399
负责人：
MIKAMI Tomohisa
金额：
$ 1.15万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570399/
关键词：
Atherosclerosis Ultrasound Noninvasive measurement Intravascular measurement 血管弾性率

项目摘要

1. Measurement of arterial wall thicknessWe proposed three kinds of signal processings on an ultrasonic echo for obtaining arterial wall thickness to measure elastic properties of the artery using ultrasound.Accuracy of methods was examined by computer simlation and by in vitro experiments. The thickness measurement by spectral analysis of the echo attained the accuracy of better than 5 micron and minimum detectable thickness of about 0.3 mm, when ultrasound of 5 MHz was used.2. Development of intravascular ultrasonic transducerAn intravascular ultrasonic transducer for measuring regional elasticity along the aorta was developed. The transducer consists of PZT element, a flexible Ni-Ti wire for positioning the element and a catheter for blood pressure measurement, so as to obtain simultaneously four parameters concerning Young's modulus of the artery; i.e., diameter of the artery, pulsatile diameter change, artyerial wall thickness and pulse pressure. The progressive increase in Young's modulus of the aorta with distance to peripherals was found in in vivo experiments performed on dogs.3. Clinical measurement of arterial elasticityPressure strain elastic modulus of the abdominal aorta was noninvasively measured in 70 healthy subjects, 31 patients with coronary artery disease, and 36 patients with hypertension. Significant increase of the elastic modulus found in the patient groups shows promise of early detection of atherosclerosis by this technique.4. Future progress of this projectOne future development of this project is clinical application of the intravascular ultrasonic transducer for an accurate examination of atherosclerosis, and the other is nonivasive detection ofage-related atherosclerotic change of the artery at an early stage.

1.动脉壁厚度的测量我们提出了对超声回波进行三种信号处理以获得动脉壁厚度，以利用超声测量动脉的弹性特性。通过计算机模拟和体外实验检验了方法的准确性。当使用5 MHz超声波时，通过回波频谱分析进行厚度测量，精度优于5微米，最小可检测厚度约为0.3毫米。 2．血管内超声换能器的开发开发了一种用于测量沿主动脉的区域弹性的血管内超声换能器。该传感器由PZT元件、用于元件定位的柔性镍钛丝和用于测量血压的导管组成，从而可同时获得动脉杨氏模量的四个参数；即动脉直径、脉动直径变化、动脉壁厚度和脉压。在对狗进行的体内实验中发现，主动脉的杨氏模量随着距外周距离的增加而逐渐增加。3．动脉弹性的临床测量对70名健康受试者、31名冠状动脉疾病患者和36名高血压患者进行了无创测量腹主动脉压力应变弹性模量。患者组中弹性模量的显着增加表明该技术有望早期发现动脉粥样硬化。4．项目未来进展本项目未来的发展一是血管内超声换能器的临床应用，以准确检查动脉粥样硬化，二是早期无创检测与年龄相关的动脉粥样硬化变化。