Expression of Connexin 26 (Cx26) in oral squamous cell carcinoma

连接蛋白26（Cx26）在口腔鳞状细胞癌中的表达

• 批准号: 13672118
• 负责人: IMAI Yutaka
• 金额: $ 2.24万
• 依托单位: Dokkuo University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672118/
• 关键词: Oral squamous cell carcinoma; Connexin 26 gene; Invasion; metastasis; ギャップ結合; コネキシン26遺伝子; 転移

Connexins are a family of at least 12 proteins that make up intercellular channels of gap junction. Connexin 26 (Cx26) is one of those subtypes, and it is indicated to become an index to the cancer metastasis. However, there have been no reports of the role of this gene in oral cancer.The present study was undertaken in order to investigate the expression of the Cx26 gene in oral squamous cell carcinoma (oral SCC). The relationship between these genes and clinico-pathological factors and the applicability of Cx26 as an index of cancer metastasis in oral SCC was also investigated.The results of this study suggested that Cx26 gene expressions may be associated with metastasis of oral SCC, and the expression of this gene may interact with mesenchymal tissue. Clinically, Cx26 gene expression may be useful approach in obtaining information concerning the metastasis of oral SCC cells.

连接蛋白是一个由至少 12 种蛋白质组成的家族，构成间隙连接的细胞间通道。连接蛋白 26 (Cx26) 是这些亚型之一，它被认为可以成为癌症转移的指标。然而，该基因在口腔癌中的作用尚未见报道。本研究旨在探讨Cx26基因在口腔鳞状细胞癌(oral SCC)中的表达。还探讨了这些基因与临床病理因素之间的关系以及Cx26作为口腔SCC癌症转移指标的适用性。本研究结果提示Cx26基因表达可能与口腔SCC的转移相关，并且该基因的表达可能与间质组织相互作用。临床上，Cx26基因表达可能是获取口腔鳞状细胞癌细胞转移信息的有用方法。

项目成果

Imai Y, Narikawa K, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell carcinoma and its clinico-pathological significant"Cranio-Maxillofacial Surgery. 30. 285-285

Imai Y、Narikawa K、Akimoto K、Fujibayashi T：“口腔鳞状细胞癌中连接蛋白 26 基因的表达及其临床病理意义”颅颌面外科。

Imai Y, Narikawa K, Fujita Y, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell arcinoma and itsclinico-pathological significant"Cranio-Maxillofacial Surgery. 30. 285-285 (2002)

Imai Y、Narikawa K、Fujita Y、Akimoto K、Fujibayashi T：“口腔鳞状细胞癌中连接蛋白 26 基因的表达及其临床病理意义”颅颌面外科。

Imai Y, Narikawa K, Fujita Y, Akimoto K, Fujibayashi T: "Expression of connexin 26 gene in oral squamous cell carcinoma and its clinico-pathological significant"J. Cranio-Maxillofacial Surgery. 30. 285 (2002)

Imai Y，Narikawa K，Fujita Y，Akimoto K，Fujibayashi T：“口腔鳞状细胞癌中连接蛋白 26 基因的表达及其临床病理意义”J。