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Immuno-morphological Study on the Function of Dendritic Reticulum Cell in Germinal Center

生发中心树突状网状细胞功能的免疫形态学研究

基本信息

批准号：
59440030
负责人：
IMAI Yutaka
金额：
$ 12.16万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1985
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-59440030/
关键词：
Lymph follicle Germinal center 樹枝状細網細胞

项目摘要

The dendritic reticulum cells (DRCs) in the lymph nodes and extra-nodal lymph follicles of human, mouse and rat were observed in light and electron microscopy under the physiological, stimulated and immunized conditions as well as ontogenesis.We are presenting the results as follows:(1) The DRCs were almost confined to the germinal center. They were divided into the DRCs without labyrinth structure and with labyrinth structure. The former was widely distributed in whole germinal center. The latter was scatteredly distributed in the upper portion of the light zone.(2) The DRCs with labyrinth structures had several complicated cytoplasmic extensions. In cross sections, the labyrinth structures bore a resemblance to those of Brussels sprout. The cytoplasmic processes of germinal center cells showed no concern with the labyrinth structures.(3) The cytoplasmic plasmalemma of DRCs showed a positivity for Ia-like antigen. Between the DRCs and lymphoid cells, desmosome and/or desmosomal junctions were frequently observed.(4) The fibroblastic reticulum cells, forming the stroma of lymph nodes, were transformed into the typical DRCs with labyrinth structures in the cap area.(5) In the well-developed secondary follicles, the immune complex trapping cells, out of DRCs, were mainly localized in the cap area.(6) The early complement components in classical pathway and their complement receptors were detected on the cell surface of DRCs in the germinal centers of lymph nodes and extranodal lymph follicles.

在生理、刺激、免疫和个体发育条件下，用光镜和电镜观察了人、小鼠和大鼠淋巴结和结外淋巴滤泡中的树突状网状细胞（dendriticreticulumcells，DRCs），结果表明：（1）DRCs几乎局限于生发中心;将其分为无迷宫结构和有迷宫结构两类。前者广泛分布于整个老年中心。后者散在分布于亮区上部。(2)树突状细胞具有复杂的胞质延伸结构，呈迷宫状结构。在横截面上，迷宫结构与布鲁塞尔芽的迷宫结构相似。生发中心细胞的胞质突起与迷路结构无关。(3)树突状细胞胞浆膜呈Ia样抗原阳性。在树突状细胞和淋巴细胞之间，经常观察到桥粒和/或桥粒连接。(4)淋巴结间质中的成纤维细胞转化为典型的树突状细胞，在帽区形成迷宫状结构。(5)在发育良好的次级卵泡中，免疫复合物捕获细胞主要位于帽区。(6)经典途径中的早期补体成分及其补体受体可在淋巴结生发中心和结旁淋巴滤泡的DRCs细胞表面检测到。