Development of adaptive glycemic control system using artificial intelligence - application of expert system -

利用人工智能开发自适应血糖控制系统-专家系统的应用-

• 批准号: 61570552
• 负责人: KAWAMORI Ryuzo
• 金额: $ 1.34万
• 依托单位: Osaka University Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570552/
• 关键词: artificial intelligence; expert system; data base; artificial pancreas; glycemic control; 血糖値クランプ; エキスパート・システム; コンパートメント・モデル

For adaptive glycemic control on diabetics, expert system has been developed combining a continuous glucose monitoring device, a personal computer system, and insulin and glucose infusion pumps. A computer system composes a noise-filter algorithm, glycemia forecasting algorithm, glucose and insulin compartment algorithm, closed-loop intravenous insulin infusion algorithm, closed-loop subcutaneous insulin infusion algorithm, glucose clamp( euglycemic-hyperinsulinemic, and hyperglycemic )algorithm, and a fail-safe algorithm.algorithm. The closed-loop subcutaneous insulin infusion succeeded in controlling the daily glycemic excursion of diabetics into near-normal range. The closed-loop intravenous insulin infusion was carried out on 61 diabetics to deduce an algorithm to determine the insulin dosage of intensified insulin therapy followed after one-day application of artificial endocrine pancreas on diabetics. With the obtained algorithm, 21 diabetics was successively controlled with continuous subcutaneous insulin infusion after strict glycemic control with the artificial endocrine pancreas.These data indicated that the developed expert system is quite useful for strict glycemic control on diabetics.

为了对糖尿病患者进行自适应血糖控制，开发了一种专家系统，该系统结合了连续血糖监测设备、个人计算机系统以及胰岛素和葡萄糖输注泵。一种计算机系统，包括噪声滤波算法、血糖预测算法、葡萄糖和胰岛素隔室算法、闭环静脉胰岛素输注算法、闭环皮下胰岛素输注算法、葡萄糖夹(正常血糖-高胰岛素和高血糖)算法和故障安全算法。闭环皮下注射胰岛素成功地将糖尿病患者的每日血糖漂移控制在接近正常的范围。对61例糖尿病患者进行胰岛素闭环静脉输注，推导出糖尿病患者应用人工内分泌胰腺1天后强化胰岛素治疗的胰岛素用量的确定算法。利用该算法，对21例糖尿病患者在人工内分泌胰腺严格控制血糖后，连续皮下注射胰岛素，结果表明，所开发的专家系统对糖尿病患者的血糖控制具有较高的实用价值。

项目成果

朝川信之: 大阪大学医学雑誌. 36(12). 387-395 (1986)

浅川伸行：大阪大学医学杂志 36(12) (1986)。

Nao K et al.: "How to determine the insulin dosage of intensified insulin therapy from srtificial pancreas" submitted to J Japan Diab Soc.

Nao K 等人：“如何确定人工胰腺强化胰岛素治疗的胰岛素剂量”提交给 J Japan Diab Soc。

朝川信之: 大阪大学医学雑誌. 36. 387-395 (1986)

浅川伸之：大阪大学医学杂志 36. 387-395 (1986)

Sekiya M et al.: "The differenc in glycemic control with two closed-loop system." Jpn J Artif Organs. 17. 200-203 (1988)

Sekiya M 等人：“两个闭环系统在血糖控制方面的差异。”

Asakawa N.: Diabetes Research. 5. 193-198 (1987)

Asakawa N.：糖尿病研究。