New insulin resistance regulatory factor "susceptibility to fat loading"

新的胰岛素抵抗调节因子“脂肪负荷敏感性”

• 批准号: 21300255
• 负责人: KAWAMORI Ryuzo
• 金额: $ 11.4万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300255/
• 关键词: 骨格筋細胞内脂質; インスリン抵抗性; 糖尿病; 身体活動; アディポネクチン

(Aim) We investigated the effect of high fat diet(HFD) on metabolism in skeletal muscle.(Method) Three days HFD were provided to healthy men after 3 days normal fat diet.(Results) We observed negative correlation between changes in intramyocellular lipid(IMCL) and changes insulin sensitivity(GIR) after HFD. Microarray analysis demonstrated that significant changes of metabolic pathway was observed in high responder group(HR ; increased IMCL and decreased GIR after HFD), but not in low responder group(LR). Gene expression level of fat uptake and oxidation were elevated in HR group.(Conclusion) Our data suggested that gene expression response after HFD in skeletal muscle is associated with IMCL and GIR changes.

(Aim)研究了高脂饮食对骨骼肌代谢的影响。（方法）正常脂肪饮食3天后，给予健康男性3天高脂饮食。（结果）HFD后肌细胞内脂质（IMCL）变化与胰岛素敏感性（GIR）变化呈负相关。基因芯片分析显示，高反应组（HR ; HFD后IMCL增加，GIR降低）的代谢途径发生了显著变化，而低反应组（LR）的代谢途径没有发生变化。HR组脂肪摄取和氧化基因表达水平升高。（结论）HFD后骨骼肌的基因表达反应与IMCL和GIR的变化有关。

项目成果

Susceptible Factors for Intramyocellular Lipid Accumulation by Dietary Fat Loading in Non-Obese Men

非肥胖男性膳食脂肪负荷导致肌细胞内脂质积累的易感因素

• 发表时间: 2010
• 作者: 櫻井裕子;田村好史;河盛隆造;綿田裕孝
• 通讯作者: 綿田裕孝

Determinants of intramyocellular lipid accumulation after dietary fat loading in non-obese men.

• DOI: 10.1111/j.2040-1124.2010.00091.x
• 发表时间: 2011-08-02
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Sakurai Y;Tamura Y;Takeno K;Kumashiro N;Sato F;Kakehi S;Ikeda S;Ogura Y;Saga N;Naito H;Katamoto S;Fujitani Y;Hirose T;Kawamori R;Watada H
• 通讯作者: Watada H

ヒトにおける高脂肪食負荷が、骨格筋細胞内脂質蓄積とインスリン抵抗性発生に与える影響とその規定因子

高脂饮食对人体骨骼肌细胞内脂质积累和胰岛素抵抗发展的影响及其影响因素

• 发表时间: 2009
• 作者: 田村好史;綿田裕孝;河盛隆造
• 通讯作者: 河盛隆造

Diabetes and Exercise :Intramycellular Lipid Accumulation and Insulin Sensitivity.

糖尿病与运动：肌细胞内脂质积累和胰岛素敏感性。

• 发表时间: 2009
• 作者: 池田真一、田村好史;他;Tamura Y.;Tamura Y.
• 通讯作者: Tamura Y.

Changes in Intramyocellular Lipid Accumulation and Insulin Sensitivity after High-Fat Loading Are Associated with Transcriptional Response in Human Skeletal Muscle.

高脂肪负荷后肌细胞内脂质积累和胰岛素敏感性的变化与人类骨骼肌的转录反应相关。

• 发表时间: 2011
• 作者: Kakehi S;Tamura Y;Sakurai Y;Takeno K;Kawaguchi M;Sato F;Ikeda S;Kim M;Yamamoto R;Ogura Y;Saga N;Katamoto S;Fujitani Y;Hirose T;Kawamori R,Watada H
• 通讯作者: Kawamori R,Watada H