The development of wrist-watch type glucose monitoring system and its clinical applications

手表式血糖监测系统的研制及其临床应用

• 批准号: 60570530
• 负责人: KAWAMORI Ryuzo
• 金额: $ 1.22万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570530/
• 关键词: needle-type glucose sensor; wearable artificial endocrine pancreas; telemetry; ブドウ糖センサ; 生体適合膜; ノイズ・フィルター

A telemetry glucose monitoring system consists of a transmitter connected by a needle-type glucose sensor and a receiver. The needle-type glucose sensor is a hydrogen-peroxide electrode covered by immobilized glucose oxidase, which generates a very weak direct current depending on glucose concentration in surrounding fluid. The transmitter converts current signals generated by a needle-type glucose sensor to a very-high-frequency (VHF) audio signal. The transmitter consists of a current-voltage-converting amplifier, a voltage-frequency converter, and a lithium battery. The receiver is composed of a VHF oscillator, a frequency modulator, electric filters, a frequency-voltage converter, and an alarm circuit and batteries. By modifying these devices, the prototype of wrist-watch type glucose monitoring system was established. Continuous glucose monitorings by this device in insulin-treated diabetic patients were attempted on a long-term basis. Even though the meal, exercise, and insulin administration regimes were identical in each patient for the specified period, there existed marked day-by-day variations in glycemic response. Thus, it was concluded from these stidies that closed-loop glycemic control is essential to overcome changes in characteristics such as variations in meal ingestion and absorption and in insulin sensitivity.

一种遥测血糖监测系统，包括通过针状葡萄糖传感器连接的发送器和接收器。针式葡萄糖传感器是一种由固定化葡萄糖氧化酶覆盖的过氧化氢电极，根据周围液体中的葡萄糖浓度产生非常弱的直流电。发射器将针状葡萄糖传感器产生的电流信号转换为甚高频（VHF）音频信号。发射器由电流-电压转换放大器、电压-频率转换器和锂电池组成。接收机由甚高频振荡器、调制器、电滤波器、频率电压变换器、报警电路和电池组成。通过对这些装置的改造，建立了腕表式血糖监测系统原型。该装置在胰岛素治疗的糖尿病患者中进行了长期的连续血糖监测。尽管在指定的时间段内，每位患者的饮食、运动和胰岛素给药方式都是相同的，但血糖反应每天都有明显的变化。因此，从这些研究中得出结论，闭环血糖控制对于克服膳食摄取和吸收变化以及胰岛素敏感性等特征的变化至关重要。

项目成果

KAWAMORI,R.: "Diabetes 1985" Elsevier Science Publishers B.V., 1112 (1986)

KAWAMORI,R.：“糖尿病 1985” Elsevier Science Publishers B.V.，1112 (1986)

KAWAMORI,R.: "Progress in Articficial Orgons 1985" ISAO Press, NewYork, 1678 (1986)

KAWAMORI,R.：“1985 年人工器官的进展”ISAO Press，纽约，1678（1986）

Shichiri,M.: Diabetes Care. 9. 298-301 (1986)

Shichiri,M.：糖尿病护理。

Shichiri, M.: "Optimized algorithms for closed-loop glycemic control systems. In: Beyer J, Albisser A.M., Schrezenmeir J, Lehmann L, eds." Computer systems for insulin adjustment in diabetes melltius. Hedingen: Panscienta-Verlag, 1985: 171-183. 171-183 (1

Shichiri, M.：“闭环血糖控制系统的优化算法。见：Beyer J、Albisser A.M.、Schrezenmeir J、Lehmann L 编辑。”

Shichiri, M.: "Long-term application of wearable artificial endocrine pancreas - closed-loop intravenous vs subcutaneous insulin infusion -" Life Support, in press, 1987.(1987)

Shichiri, M.：“可穿戴人工内分泌胰腺的长期应用 - 闭环静脉注射与皮下胰岛素输注 -”生命支持，出版，1987 年。（1987 年）