A study on a method for ddiagnosing arteriosclerosis by means of pulse wave velocity

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Difference of arterial pulse wave velocity (PWV) between patients with diseases that might decrease the arterial compliance (patient) and subjects without those diseases (normals) was examined. First, physiological factors that might influence PWV were examined. The statistically significant factors were age, systolic blood pressure, and diastolic blood pressure. Second, a linear predicting function that could predict PWV by means of the above mentioned factors was obtained by multiple regression analysis, and the values computed by this function were subtracted from the measured PWVs. Finally, these residuals of the normals were compared with those of the patients in each disease category, and a correlation coefficient between the residuals and the measurements of each serum lipids, i.e., total cholesterol, phospholipid, triglyceride, and beta-lipoprotein was examined for all the subjects. Consequently, no significant difference was found between PWVs of the normals and those of the patients, and no significant correlation was obtained between PWV and each of serum lipid levels.