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Chemical Synthesis of Biodegradable Polyesters Utilizing Sugar Biomasses.

利用糖生物质化学合成可生物降解聚酯。

基本信息

批准号：
11217208
负责人：
OKADA Masahiko
金额：
$ 14.66万
依托单位：
Chubu University (2000-2002)Nagoya University (1999)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

1. Synthesis of Polyesters and Related Polymers Containing Sugar Diols : Series of polyesters, poly (ester amide) s, poly (ester carbonate) s, and polycarbontes were synthesized from sugar-based raw materials. Sugar diols such as 1, 4:3, 6-dianhydro-D-glucitol (DAG), 1, 4:3, 6-dianhydro-D-mannitol (DAM), 1, 4:3, 6-dianhydro-L-iditol (DAl) were chiefly employed as diol components in polycondensations. Dicarboxylic acid derivatives containing furan moieties were used as dicarboxylic acid components in some cases.2. Biodegradability of Sugar-Based Polyesters and Related Polymers : The biodegradability of the sugar-based polyesters and the related polymers were examined by three different methods, i. e., soil burial degradation, activated sludge treatment, and enzymatic degradation tests. The biodegradability varied widely, depending on the molecular structure of the polymers. In general, polymers containing unsymmetrical DAG units showed higher biodegradability than the corresponding polymers containing symmetrical DAM and DAI units.3. Synthesis of Chitin-graft-oligoesters and Related Polymer : Chitin-graft-oligoesters were prepared by the ring-opening polymerization of ε-caprolactone in the presence of partially deacetylated chitin (PDC) using water as a medium. A novel N-selective ester functionalized chitin derivative was prepared by a Michael-type nucleophilic addition of an amino group of PDC to ethyl acrylate in phosphate buffer/methanol. Poly (vinyl alcohol)-graft-oligoester was synthesized by the reaction of PVA and ε-caprolactone in DMSO. The biodegradability as well as the thermal and surface properties of these polymer films were examined in detail. On the basis of the present research, useful and important guidelines have been established for designing polyesters and related polymers having a controlled biodegradability from renewable sugar-based raw materials.

1.含糖二醇的聚酯和相关聚合物的合成：从糖基原料合成了一系列聚酯、聚（酯酰胺）、聚（酯碳酸酯）和聚碳酸酯。糖二醇如1，4：3，6-二脱水-D-葡萄糖醇（DAG）、1，4：3，6-二脱水-D-甘露糖醇（DAM）、1，4：3，6-二脱水-L-艾杜糖醇（DAl）主要用作缩聚反应中的二醇组分。在某些情况下，含有呋喃部分的二羧酸衍生物被用作二羧酸组分。糖基聚酯和相关聚合物的生物降解性：通过三种不同的方法检测糖基聚酯和相关聚合物的生物降解性。例如，土壤掩埋降解、活性污泥处理和酶降解试验。生物降解性变化很大，这取决于聚合物的分子结构。一般来说，含不对称DAG单元的聚合物比含对称DAM和DAI单元的聚合物具有更高的生物降解性.甲壳素接枝低聚酯及相关聚合物的合成：以水为介质，在部分脱乙酰甲壳素（PDC）存在下，通过ε-己内酯开环聚合制备了甲壳素接枝低聚酯。在磷酸盐缓冲液/甲醇中，通过丙烯酸乙酯与PDC的氨基发生Michael型亲核加成反应，合成了一种新型的N-选择性酯功能化甲壳素衍生物。以聚乙烯醇（PVA）和ε-己内酯（ε-己内酯）为原料，在二甲基亚砜（DMSO）中合成了聚乙烯醇接枝低聚酯。这些聚合物薄膜的生物降解性以及热性能和表面性能进行了详细研究。在本研究的基础上，已经建立了用于设计聚酯和相关聚合物的有用和重要的指导方针，所述聚酯和相关聚合物具有来自可再生糖基原料的受控生物降解性。