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Physiological roles in neutral and humoral control of venous system

静脉系统中性和体液控制的生理作用

基本信息

批准号：
63570036
负责人：
OHHASHI Toshio
金额：
$ 1.34万
依托单位：
Shinshu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

To evaluate the mode of neural and humoral control on venous smooth muscles, we have undertaken to study regional differences in the density of aminergic nerve fibers of the rabbit, canine, and monkey venous walls by glyoxylic acid-histochemical techniques, and in the potency in vasoconstrictive and vasodilative responses of isolated canine and monkey smooth muscles. The experimental results are summarized as follows: (1) The aminergic nerve fibers innervate most densely in the portal vein, inferior caval vein, renal vein, and common iliac vein. (2) The nerve fibers present sparsely in the venous walls of femoral vein and lateral saphenous vein at the intramuscular portion. (3) The heterogeneity in the aminergic innervation was observed in the monkey, canine, and rabbit venous system, but the density of aminergic nerve fibers was highest in the monkey veins and lowest in the rabbit. (4) There were marked heterogeneity in pharmacological responses to vasoconstrictive and vasodilative agents in isolated monkey and canine veins. (5) Thus, from the pharmacological points of view, the responsiveness of venous smooth muscle was divided as following three groups: (1) abdominal caval vein, iliac veins, renal vein, and portal vein; (2) thoracic caval vein, extremity veins, and cervical veins; (3) axillar vein and subclavian vein. (6) In monkey venous system, the third group was not distinguished, therefore the third grouped veins may be a characteristic feature of the pharmacological responses of venous smooth muscles in animal with four extremities, comparing with monkey and human being.

为了评估神经和体液对静脉平滑肌的控制模式，我们采用乙醛酸组织化学技术研究了兔、犬和猴静脉壁胺能神经纤维密度的区域差异，以及犬和猴离体平滑肌血管收缩和血管扩张反应的功效。实验结果表明：(1)门静脉、下腔静脉、肾静脉和髂总静脉的胺能神经纤维分布最密集。(2)肌内部分股静脉和外侧隐静脉静脉壁内神经纤维稀疏分布。(3)猴、犬和兔静脉系统的胺能神经分布存在异质性，但猴静脉的胺能神经纤维密度最高，兔静脉的胺能神经纤维密度最低。(4)猴、犬离体静脉对血管收缩剂和舒张剂的药理反应存在明显的异质性。(5)因此，从药理学角度将静脉平滑肌的反应性分为以下三组：(1)腹腔静脉、髂静脉、肾静脉、门静脉；(2)胸腔静脉、四肢静脉、颈静脉；(3)腋窝静脉和锁骨下静脉。(6)在猴的静脉系统中，没有区分出第三组静脉，因此与猴和人相比，第三组静脉可能是四肢动物静脉平滑肌药理反应的一个特征。