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ROLE OF DYSFUNCTIOINAL DOPAMINERGIC SYSTEM ON PATHOGENESIS OF POLYCYSTIC OVARIAN SYNDROME

功能障碍的多巴胺能系统在多囊卵巢综合征发病机制中的作用

基本信息

批准号：
63570790
负责人：
MORI Hiroyuki
金额：
$ 0.26万
依托单位：
TEIKYO UNIVERSITY, SCHOOL OF MEDICINE (1989)大分医科大学 (1988)
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

The dopaminergic system was studied in patients with polycystic ovarian syndrome(PCOS), and also in rat's ovary in vitro by the stimulation of dopamine-agonists. LH, FSH and PRL were measured before and after 3 months administration of bromocriptine in patients with various types of PCOS. LH and PRL were dramatically decreased in every type of PCOS, while FSH remained normal. The depletion of responses of LH and PRL to LHRH and TRH was observed, however, the response of FSH showed no remarkable cliange. 80% of PCOS ovulated in response to the bromocriptine treatment, and about 30-50% of patients became pregnant in every type of PCOS. Moreover, little ovarian hyperstimulation syndrome was pointed out in present study, which was often complicated with the usual methods of the induction of ovulation in PCOS. These facts indicate that the dysfunction of the dopaminergic activity is one of the cause of PCOS, and that the replacement therapy by the dopaminergic agonists is rational treatment of PCOS. The rat's granulosa cells and luteal cells were cultured in the medium with the dopaminergic agonists. Both granulosa and luteal cells increased progesterone and 20 alpha OH-progesterone production by the dopaminergic agonist, which were indifferent with cAMP accumulation. This facts suggest that replaced dopamine effected on the ovaries not on the hypothalmopituitary area, which required further experiments.

本实验研究了多囊卵巢综合征（PCOS）患者及离体大鼠卵巢多巴胺能系统的变化。方法：对10例不同类型的PCOS患者在服用溴隐亭3个月前后分别测定LH、FSH和PRL。各型PCOS患者LH、PRL均明显下降，FSH正常。LH和PRL对LHRH和TRH的反应性降低，而FSH的反应性无明显变化。80%的PCOS患者对溴隐亭治疗有排卵反应，每种类型的PCOS患者中约有30-50%的患者怀孕。此外，本研究还指出，PCOS患者的卵巢过度刺激综合征很少发生，常与常规促排卵方法并发。提示多巴胺能功能障碍是多囊卵巢综合征的病因之一，多巴胺能受体激动剂替代治疗是多囊卵巢综合征的合理治疗方法。将大鼠颗粒细胞和黄体细胞培养在含有多巴胺能激动剂的培养基中。颗粒细胞和黄体细胞增加孕酮和20 α OH-孕酮生产的多巴胺能激动剂，这是无关紧要的cAMP积累。这一事实表明，替代多巴胺对卵巢的影响而不是对下丘脑垂体区的影响，这需要进一步的实验。