Phase 2 Kp-10 for Dopamine Agonist Intolerant Hyperprolactinemia IND 74,977

摘要 高催乳素血症是由脑垂体瘤和药物或病理中断引起的 多巴胺能通路。催乳素水平升高也会导致多种水平的内分泌功能障碍。 生殖级联包括促性腺激素减退、月经不调、勃起 功能障碍、不孕不育和骨质流失。最近的数据表明，高催乳素血症导致 Kispeptin的表达，这会导致GnRH分泌减少，并导致低促性腺激素 性腺功能减退。在小鼠中，外周给药可以恢复GnRH的分泌，促性腺激素的释放， 和卵巢周期。人类高催乳素血症患者的外源性Kispeptin(初步数据) 政府还恢复了促性腺激素的分泌。因此，这个应用程序探索了外源的使用 脉冲式Kispeptin治疗不能耐受高催乳素血症的患者 目前的治疗方法。

Abstract Hyperprolactinemia is caused by pituitary tumors and pharmacologic or pathologic interruption of dopaminergic pathways. Elevated prolactin levels can also cause endocrine dysfunction at multiple levels of the reproductive cascade including hypogonadotropic hypogonadism, irregular menstruation, erectile dysfunction, infertility and bone loss. Recent data suggests that hyperprolactinemia causes reduced kisspeptin expression, which then leads to reductions in GnRH secretion, and hypogonadotropic hypogonadism. In mice, peripheral kisspeptin administration restores GnRH secretion, gonadotropin release, and ovarian cycles. In human patients with hyperprolactinemia (Preliminary Data), exogenous kisspeptin administration also restores gonadotropin secretion. Thus, this application explores the use of exogenous pulsatile kisspeptin as a therapeutic alternative for patients with hyperprolactemia who are intolerant to current therapies.