Post-lesion plasticity in the auditory central nervous system

听觉中枢神经系统损伤后可塑性

• 批准号: 63570805
• 负责人: TANIGUCHI Ikuo
• 金额: $ 1.22万
• 依托单位: TOKYO MEDICAL AND DENTAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63570805/
• 关键词: Regeneration; Synaptic reorganization; Post-lesion plasticity; Inferior colliculus; Commissure of inferior colliculus; Auditory central nerve

Regenerative responses to damage in the central nervous system (CNS) can be elicited may two types of mechanisms. One is regenerative sprouting or axonal regeneration from damaged neurons and the other is collateral sprouting from intact neurons. Collateral sprouting occurs widely in the CNS, as well as in the peripheral nervous system. On the other band, in the mammalian CNS, axonal regeneration is usually abortive. In this study, we observed axonal regeneration in the commissure of the inferior colliculus (CIC) of mice following its transection. While evidence concerning morphological re-organization of the CNS is accumulating, little is known about the consequent recovery of function at the cellular level. The purpose of this study was to examine whether the regenerated CIC axons could re-establish synapses with neurons in the inferior colliculus (IC). If the synapses were re-established, our concern was their functional features. Some statistical differences were found between the two neuronal populations of the operated mice and the unoperated controls. However, the re-established synapses seem to be properly re-organized into newly established neural circuits which may be similar to those in the intact animals. This means the restitution of synaptic integrity occurs even after mechanical transection of the axons within mammalian brain.

对中枢神经系统（CNS）损伤的再生反应可以通过两种类型的机制引起。一种是损伤神经元的再生发芽或轴突再生，另一种是完整神经元的侧枝发芽。侧枝发芽广泛发生在中枢神经系统以及周围神经系统中。另一方面，在哺乳动物中枢神经系统中，轴突再生通常是流产的。本研究观察了小鼠下丘连合（CIC）切断后轴突再生的情况。虽然有关CNS的形态学重组的证据正在积累，但对随后在细胞水平上的功能恢复知之甚少。本研究的目的是观察再生的CIC轴突是否能与下丘神经元重建突触。如果突触重新建立，我们关心的是它们的功能特征。在手术小鼠和未手术对照组的两个神经元群体之间发现了一些统计学差异。然而，重新建立的突触似乎被适当地重新组织成新建立的神经回路，这可能与完整动物中的神经回路相似。这意味着即使在哺乳动物脑内的轴突被机械切断后，突触完整性的恢复也会发生。

项目成果

I.Taniguchi: "Axonal regeneration after transection of commissure of the inferior colliculus,In:Post-Lesion Neural Plasticity." Springer-Verlag(Berlin), 555-563 (1988)

I.Taniguchi：“下丘连合横断后的轴突再生，见：损伤后神经可塑性。”

I.Taniguchi: "Plastic reorganization after transection of the commissure of the inferior colliculus" Proc.Japan Acad.58. 181-184 (1982)

I.Taniguchi：“下丘连合横断后的塑性重组”Proc.Japan Acad.58。

田中英和: "下丘交連線維切断後のシナプス再形成" Audiology Japan. 32. 411-412 (1989)

Hidekazu Tanaka：“下丘连合纤维横切后的突触再生”日本听力学 32. 411-412 (1989)。

I.Taniguchi: "Axonal regeneration after transection of the commissure of the inferior colliculus,In:Post-Lesion Neural Plasticity(H.Flohr,ed.)" Springer-Verlag(Berlin), 555-563 (1988)

I.Taniguchi：“下丘连合横断后的轴突再生，In：Post-Lesion Neural Plasticity（H.Flohr，编辑）”Springer-Verlag（柏林），555-563（1988）

I. Taniguchi: "Targets of the re-established axons of the commissure of the inferior colliculus after its transection" J. Physiol. Soc. Japan 50: 503, 1988.

I. Taniguchi：“下丘连合横断后重建轴突的目标”J. Physiol。