A NEUROPHYSIOLOGICAL STUDY ON COCHLEAR IMPLANTATION BY OPTICAL IMAGING

人工耳蜗植入的神经生理学光学成像研究

• 批准号: 06454484
• 负责人: TANIGUCHI Ikuo
• 金额: $ 4.61万
• 依托单位: TOKYO MEDICAL AND DENTAL UNIBERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454484/
• 关键词: COCHLEAR IMPLANT; OPTICAL IMAGING; NEUROPHYSIOLOGICAL STUDY; COCHLEAR ELECTRICAL STIMULATION17GA01 : Horikawa, J.and I.Taniguchi

To observe the spatio-temporal representation of cochlear electrical stimulation in the auditory cortex, we applied the optical imaging technique in the guinea pig. The cortical activity induced by acoustic and cochlear electrical stimulation were recorded with a 12*12 photodiode array and a voltage-sensitive dye. For electrical stimulation wire electrodes were inserted into the scala tympani and the scala vestibuli of the cochlea. Bipolar stimulation with single electrical pulses to the cochlea induced two active spots separated in the auditory cortical fields, anterior and dorsocaudal, which are tonotopically organized. Such active spots were transiently localized in the cortex also in acoustic stimulation. However, the active spots induced by electrical stimulation moved transversally across isofrequency contours in the auditory cortex and spread broadly throughout the cortex with time. The magnitude of responses as a function of electrical intensity showed a very narrow dynamic range. In addition, the response latencies were almost constant for various stimulus intensities. These results were significantly different from those for normal sound stimulation. This suggests that electrical stimulation bypasses the sensory transducer mechanism, and activates directly the nerve terminals in the cochlea.

应用光学成像技术观察耳蜗电刺激在豚鼠听皮层的时空表征。用12 × 12光电二极管阵列和电压敏感染料记录声刺激和耳蜗电刺激引起的皮层活动。对于电刺激，将导线电极插入耳蜗的鼓阶和前庭阶中。双极刺激与单电脉冲耳蜗诱导两个活跃点分离的听觉皮层领域，前和背尾侧，这是tonotopically组织。这种活性点在声刺激下也短暂地定位在皮层中。然而，由电刺激引起的活动点横向移动跨越听觉皮层的等距轮廓，并随着时间的推移广泛分布在整个皮层。作为电强度的函数的响应幅度显示出非常窄的动态范围。此外，对不同刺激强度的反应潜伏期几乎是恒定的。这些结果与正常声音刺激的结果有显著差异。这表明电刺激绕过感觉换能器机制，直接激活耳蜗中的神经末梢。

项目成果

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Taniguchi,I.et al.：“耳蜗内电刺激诱导的听觉皮层神经活动的光学成像。”

森山俊男,他: "異なった方向からの音刺激によるモルモット皮質聴覚領の両耳応答の時空間パターン" Audiol.Jpn.38. 735-736 (1995)

Toshio Moriyama等人：“豚鼠听觉区域对不同方向声音刺激的双耳反应的时空模式”Audiol.Jpn.38（1995）。

Hosokawa, Y., Horikawa, M.Nasu and I.Taniguchi: "Binaural interaction in the guinea pig auditory cortex observed by optical recording." Assoc.Res.Otolaryngol Abstr. 23-93 (1994)

Hosokawa, Y.、Horikawa、M.Nasu 和 I.Taniguchi：“通过光学记录观察到豚鼠听觉皮层的双耳相互作用。”

Moriyama,T.et al.: "Responses of inferior collicular neurons of the FM bat,Eptesicus fuscus,to pulse trains with varied pulse amplitudes." Hearing Res.79. 105-114 (1994)

Moriyama, T. 等人：“FM 蝙蝠（Eptesicus fuscus）的下丘神经元对不同脉冲幅度的脉冲序列的反应。”

Moriyama,T.et al.: "Optical recording of azimuth representation in guinea pig auditory cortex." Proceedings of IBRO Statellite Symposium "Processing in Auditory and Language Cortex". (in press). (1996)

Moriyama,T.et al.：“豚鼠听觉皮层方位角表示的光学记录。”