Physiological Function of Polyamines Which are Covalently Linked to Peptidoglycan in Bacteria

细菌中与肽聚糖共价连接的多胺的生理功能

• 批准号: 01560112
• 负责人: KAMIO Yoshiyuki
• 金额: $ 1.22万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01560112/
• 关键词: polyamine; Cadaverine; Spermidine; peptidoglycan; リピド中間体:ポリアミン転移酵素; ジアミン; リピド中間体:ジアミン転移酵素; 偏性嫌気性菌

ABSTRACTPolyamine covalently linked to the cell wall peptidoglycan was found to occur in strictly anaerobic lactate fermenting bacteria. The strains included Selenomonas ruminantiom, S. sputigena, Veillonellaalcalescens, V parvula, Anaerovibrio lipolytica and Megasphaera elsdenii.In A. lipolytica, spermidine is linked covalently to the alpha-carboxylgroup of the peptidoglycan, while in other strains, putrescine and cadaverine are linked to the same group of the peptidoglycan. All the studied anaerobes containing polyamine linked to the peptidoglycan studied hitherto possessed neither phospatidylglvcerol, cardiolipin normurein lipoprotein in their envelopes. These microorganisms were resistant to monensin which is an ionophore for potassium iom.

摘要在严格厌氧乳酸发酵菌中发现了与细胞壁肽聚糖共价连接的多胺。菌株包括反刍单胞菌、恶臭单胞菌、细孔单胞菌、小苗单胞菌、多脂性厌弧菌和叶氏巨孢子菌。在A. lipolytica中，亚精胺与肽聚糖的α -羧基共价连接，而在其他菌株中，腐胺和尸胺与肽聚糖的同一组共价连接。所有被研究的厌氧菌都含有与肽聚糖相连的多胺，迄今为止所研究的厌氧菌在其包膜中既没有磷脂酰甘油，也没有心磷脂normurein脂蛋白。这些微生物对钾离子载体莫能菌素具有耐药性。

项目成果

Yoshiyuki Kamio: "The Rumen Ecosystem:The microbial Metalolism and its Regulation(SpringerーVerlag)" T.Hoshino,R.Onodera,H.Minato and K.Itabashi, 223 (1990)

Yoshiyuki Kamio：“瘤胃生态系统：微生物代谢及其调节（Springer-Verlag）” T.Hoshino、R.Onodera、H.Minato 和 K.Itabashi，223（1990）

M.Sato,H.Minato K.Izaki and Y.Kamio: "Occurrence of polyamine covatently linked to the peptidoglycan in strictly anaerobic lactate fermenting bacteria" J.Bacteriology.

M.Sato、H.Minato K.Izaki 和 Y.Kamio：“在严格厌氧乳酸发酵细菌中与肽聚糖共价连接的多胺的出现”J.Bacteriology。

Y.Kamio,T.Hirao M.Sato,K.Izaki and Y.Kamio: "Chemical structure of the peptidogylcan in AnaeroVibrio lipolytia:spermidine links covatently in the peptidoglycan." J.Biological chemistly.

Y.Kamio、T.Hirao M.Sato、K.Izaki 和 Y.Kamio：“AnaeroVibrio lipolytia 中肽聚糖的化学结构：亚精胺在肽聚糖中共价连接。”

Y.Kamio,T.Hirao,M.Sato,K.Izaki,and Y.Kamio: "Chemicol structure of the peptidogycan in Anaerovibrio lipolytica;Spermidine links covalently in the peptidoglycan" J.Bacteriology.

Y.Kamio、T.Hirao、M.Sato、K.Izaki 和 Y.Kamio：“解脂厌氧弧菌中肽聚糖的化学结构；亚精胺在肽聚糖中共价连接”J.Bacteriology。

Y. Kamio: "Physiological and biochemical studies of polyamines which are covalently linked to peptidoglycan in anaerobic bacteria" The Rumen Ecosystem.(1990)

Y. Kamio：“厌氧细菌中与肽聚糖共价连接的多胺的生理和生化研究”瘤胃生态系统。（1990）