Responses of Cerebral Blood Flow Produced by Cutaneous Stimulation.

用激光多普勒血流计检测了麻醉大鼠皮肤区（面、前肢和足爪、背、后肢和足爪）伤害性或无害性机械刺激对皮层脑血流的影响。捏的脸，前爪和后爪15秒产生显着增加全身血压和皮质血流量，而捏的背部或刷的任何皮肤区域产生任何参数没有显着变化。在第一胸水平脊髓交易后，血压反应前爪捏被抑制，而皮质血流量的增加仍然发生。因此，结果表明，皮肤伤害性刺激后皮质血流量的增加，至少在一定程度上，独立于血压的变化和任何伴随的血管舒张。

The effect of noxious or innocuous mechanical stimulation of cutaneous areas (face, forelimb and paw, back, hind limb and paw) on cerebral blood flow in cortex was examined with laser Doppler flowmeter in anesthetized rats. Pinching of the face, forpaw and hindpaw for 15 s produced significant increases of systemic blood pressure and of cortical blood flow, whereas pinching of the back or brushing of any cutaneous area produced no significant changes in either parameter. Following spinal transaction at the first thoracic level, the blood pressure response to forepaw pinching was suppressed, whereas the increase in cortical blood flow still took place. Thus the results suggest that the increase in cortical blood flow following cutaneous noxious stimulation is, in part at least, independent of changes in blood pressure and of any concomitant vasodilatation.