Responses of Cerebral Blood Flow Produced by Cutaneous Stimulation.

皮肤刺激产生的脑血流反应。

• 批准号: 01570090
• 负责人: SATO Yuko
• 金额: $ 1.34万
• 依托单位: Tsukuba College of Technology (1990)Tokyo Metropolitan Institute of Gerontology (1989)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570090/
• 关键词: Cerebral Blood Flow; Laser Doppler Flowmetry; Rat; 麻酔ラット; 脊髄動物; 海馬局所血流

The effect of noxious or innocuous mechanical stimulation of cutaneous areas (face, forelimb and paw, back, hind limb and paw) on cerebral blood flow in cortex was examined with laser Doppler flowmeter in anesthetized rats. Pinching of the face, forpaw and hindpaw for 15 s produced significant increases of systemic blood pressure and of cortical blood flow, whereas pinching of the back or brushing of any cutaneous area produced no significant changes in either parameter. Following spinal transaction at the first thoracic level, the blood pressure response to forepaw pinching was suppressed, whereas the increase in cortical blood flow still took place. Thus the results suggest that the increase in cortical blood flow following cutaneous noxious stimulation is, in part at least, independent of changes in blood pressure and of any concomitant vasodilatation.

用激光多普勒血流仪观察麻醉大鼠皮肤区域（面部、前肢和前爪、背部、后肢和前爪）的有害性和无害性机械刺激对脑皮质血流的影响。捏脸、前爪和后爪15 s可显著增加全身血压和皮质血流量，而捏背或刷任何皮肤区域对这两项参数均无显著变化。在第一胸椎水平进行脊柱交易后，前爪挤压的血压反应被抑制，而皮质血流量仍然增加。因此，结果表明，至少在一定程度上，皮肤有害刺激后皮质血流量的增加与血压的变化和任何伴随的血管扩张无关。

项目成果

Sato, A. and Sato, Y.: "Cerebral cortical vasodilation in response to stimulation of cholinergic fibres originating in the nucleus basalis of Meynert." J. Auton. Nerv. Syst.30. S137-S140 (1990)

Sato, A. 和 Sato, Y.：“大脑皮层血管舒张是对源自 Meynert 基底核的胆碱能纤维刺激的反应。”

Hallstrom, A., Sato, A., Sato, Y. and Ungerstedt, U.: "Effect of stimulation of the nucleus basalis of Meynert on blood flow and extracellular lactate in the cerebral cortex with special reference to the effect of noxious stimulation of skin and hypoxia."

Hallstrom, A.、Sato, A.、Sato, Y. 和 Ungerstedt, U.：“刺激 Meynert 基底核对大脑皮层血流和细胞外乳酸的影响，特别是有害刺激的影响

Akio Sato: "Cerebral cortical vasodilation in response to stimulation of cholinergic fibres originating in the nucleus basalis of Meynert." Journal of Autonomic Nervous System. (1990)

Akio Sato：“大脑皮质血管舒张是对源自 Meynert 基底核的胆碱能纤维的刺激的反应。”

T.Adachi: "Cutaneous stimulation regulates blood flow in cerebral cortex in anesthetized rats." NeuroReport. 1. 41-44 (1990)

T.Adachi：“皮肤刺激调节麻醉大鼠大脑皮层的血流。”

Saeki,Y.: "Stimulation of the rostral ventrolateral mudullary neurons increases cortical cerebral blood flow via activation of the intracerebral neural pathway." Neurosci.Lett.107. 26-32 (1989)

Saeki，Y.：“刺激头侧腹外侧髓质神经元通过激活大脑内神经通路来增加皮质脑血流量。”