Study on Comparative Molecular Epidemiology on Life Span, Cansese of Diseases, Genetical Factors and Geographical Environmental Factors Among Okinawan Immigrants, Comparing With Native Okinawan

冲绳移民与冲绳本地人的寿命、疾病、遗传因素和地理环境因素的比较分子流行病学研究

• 批准号: 01570320
• 负责人: AKAMATSU Takashi
• 金额: $ 1.34万
• 依托单位: Kyorin University (1990)University of the Ryukyus (1989)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01570320/
• 关键词: Biological Markers; Amino acids; Japanese immigrants; 南米移住民; 沖縄; 比較血清疫学; 健康指標

The study of health situation among Japanese immigrants in Brazil, Bolivia, comparing with native Japanese in three prefectures (Okinawa, Iwate and Akita) have contributed to elucidate environmental risk factors, such as eating habits.This report showed that the level of serum free amino acids (17 Kinds of amino acids) reflected the characteristics of eating habits between the Japanese immigrants and Japanese residents. The levels individual amino acid were analyzed by high-performance liquid chromatography for healthy subjects residing in 1) settlement Okinawa, Bolivia, 2) Saopaulo city, Brazil, 3) Ishikawa city, Okinawa, 4) Ninohe town, Iwate, 5) Yokote city, Akita at the time of health check up.Correlation, discriminant analysis and other multi-variant analysis of serum free amino acids from each subjects groups were performed. These results of correlation matrix of each amino acid components showed high correlation coefficients between the levels of neutral amino acids in each subject groups.

通过对巴西、玻利维亚等地日本移民健康状况的研究，并与当地日本人（冲绳、岩手、秋田）的饮食习惯等环境因素进行比较，发现血清游离氨基酸（17种氨基酸）水平反映了日本移民与当地日本居民的饮食习惯特点。采用高效液相色谱法对健康体检时居住在1）玻利维亚冲绳居民区、2）巴西Saopaulo市、3）冲绳石川市、4）岩手县二户町、5）秋田横手市的健康受试者的个体氨基酸水平进行分析，并对每个受试者组的血清游离氨基酸进行相关、判别分析和其他多变量分析。各氨基酸组分的相关矩阵结果显示，各组中性氨基酸水平之间具有较高的相关系数。

项目成果

等々力 英美: "生体指標よりみた沖縄及び岩手県地域住民の食生活 ー血清遊離アミノ酸濃度についてー" 日本衛生学雑誌.

等等力惠美：“从生物指标——血清游离氨基酸浓度——角度看冲绳县和岩手县当地居民的饮食习惯——”日本卫生杂志。

等々力英美: "沖縄の長寿者の健康要因を探る" ヒュ-マンサイエンス. 2. 30-38 (1989)

Hidemi Todoroki：“探索冲绳长寿人群的健康因素”《人类科学》2. 30-38 (1989)。

津金 昌一郎: "がん死亡率の地域較差に対する生態学的アプロ-チ" 癌の臨床. 36. 425-429 (1990)

Shoichiro Tsugane：“癌症死亡率区域差异的生态方法。” 36. 425-429 (1990)

Hidemi Todoriki: "Relationship between serum amino acid and dietary nutrient intake" Japanese Journal of Hygiene.

Hidemi Todoriki：“血清氨基酸与膳食营养素摄入量之间的关系”日本卫生杂志。

S. Tugane: "Ecological Study on Cancer Mortality and Lifestyle in Japan" Jpn. J. Cancer Clin.36(3). 425-429 (1990)

S. Tugane：“日本癌症死亡率和生活方式的生态学研究”Jpn。