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Kindling as a model of neuronal plasticity (Effect of dentate nucleus lesion upon amygdaloid kindling in rats)

点燃作为神经元可塑性模型（齿状核损伤对大鼠杏仁核点燃的影响）

基本信息

批准号：
01570612
负责人：
TSURU Noriko
金额：
$ 1.28万
依托单位：
Miyazaki Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

项目摘要

Amyidaloid kindling is used to investigate whether the cerebeller dentate nuc eus participates in the neuronal plasticity of the cerebrum. In this report we studied the behavioral change, the occurrence of epileptiform events and duration of afterdischarge during amygdaloid kindling under control conditions and after a dentate lesion of the contralateral or ipsilateral cerebellum. Our results indicate that the contralateral dentate lesion induced the facilitation of the behavioral development of the amygdaloid kindling, whereas, there was only a slight increase of the spontaneous epileptiform potential of the amygdala. A second finding was that on a right amygdala which had been influenced by a left dentate lesion, there were few spikes, while on the left amygdala there were frequent spikes. In the ipsilateral dentate lesioned group there was no difference of the development of kindling and number of spikes of the amygdala comparing to the control kindling. However there was a difference of the duration of afterdischarge. As to the comparison of the ipsilateral and contralateral kindling there were significant differences of the development of kindling and spontaneous spikes but no difference of the duration of afterdischarge. These results suggest that the dentate nucleus plays an important role in amygdaloid kindling as well as in the neuronal plasticity of the amygdala, specifically. Therefore the dentate nucleus must play a role in controlling the generalization mechanism of epilepsy. However, the shortening of the afterdischarge of the dentate lesion of either side may be caused the diminution of dentate-thalamic excitatory system.If the dentate lesion was done after the accomplishment of the amygdaloid kindling, there was no significant change of the development of kindling, the duration of afterdischarge and the number of spontaneous spikes.

本实验用杏仁核点燃法研究小脑齿状核是否参与大脑神经元的可塑性。在这份报告中，我们研究了行为的变化，癫痫样事件的发生和持续时间的杏仁核点燃控制条件下，对侧或同侧小脑齿状病变后。我们的研究结果表明，对侧齿状回损伤诱导杏仁核点燃的行为发展的促进，而杏仁核的自发性癫痫样电位只有轻微的增加。第二个发现是，在受到左侧齿状核损伤影响的右侧杏仁核上，几乎没有尖峰信号，而在左侧杏仁核上，尖峰信号频繁出现。同侧齿状回毁损组大鼠点燃发展及杏仁核放电数目与对照组无明显差异。但后放电持续时间存在差异。同侧与对侧点燃比较，点燃和自发放电的发展有显着性差异，但后放电持续时间无显着性差异。这些结果表明，齿状核在杏仁核点燃以及杏仁核的神经元可塑性中起着重要的作用。因此，齿状核在癫痫的泛化机制中起一定的控制作用。而双侧齿状核毁损后放电的缩短可能是齿状核-丘脑兴奋系统的功能减弱所致，杏仁核点燃后再毁损齿状核，对点燃的发展、后放电的持续时间和自发放电的数目无明显影响。