Study on Clinical Application of Chinese Herbal Medicine as A Biological Response Modifier

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Clinical assay of Chinese herbal medicine MCX-912, which was extract from earthworm, has been carried out along with characterization based on analytical chemistry, biochemistry, cell biology, oncology, and pharmacology. The followings are the summary of results.(1) MCX-912 contains 0.8% K, Fe, Zn, Cu (total amount : 0.9%), 42.0% proteins, and 7.2% sugars.(2) Although cell killing activity of MCX-912 on EMT6 single cells is small, the lethal damage of X-irradiated cells is considerably enhanced by MCX-912.(3) Administration of MCX-912 everyday to SCC VII tumor bearing mice in their thinghs after single X-irradiation results in 1.4 times enhancement of radiation effect. Further enhancement can be achieved using MCX-912 together with hypoxiccell radiosensitizers and/or hyperthermia.(4) Decomposition of hydrogen peroxide by the Fenton's reagent is accelerated by MCX-912.(6) MCX-912 shows an antitumor effect on S180 solid tumors.(7) Administration of MCX-912 everyday to MM46 tumor bearing mice gives rise to no antitumor effect. However, number of spleen cells increases and thereby intraperitoneal MM46 cells are increasingly inactivated.(8) Number of cytotoxic T-cells in the lymphocyte subsets increases on administration of MCX-912 to patients.(9) Performance status is improved by MCX-912, due to the increase of appetite and the decrease or disappearance of sever pain for patients.