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A Study on Biomechanics of Growth/resorption of Biological Tissue as Functional Adaptation

生物组织生长/吸收的生物力学作为功能适应的研究

基本信息

批准号：
02805014
负责人：
MORIMOTO Yoshiharu
金额：
$ 1.15万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02805014/
关键词：
Biomechanics Mechanical Adaptation Remodeling Bone Intervertebral Disc Aorta Tendon リモデリング成長と変性

项目摘要

The biological issues and systems have the ability to grow, resorb, and/or deform themselves according to the changes of their environments and routine behaviors. Such ability of mechanical adaptation by remodeling is intrinsic only to the biological issue and systems. The quantitative observation and its model description are fundamental in understanding such phenomena and applying such a function in engineering field. From this viewpoint, this study investigates the following topics from experimental/mathematical approaches.1. Residual stress in bone and model of remodelingThe residual stress was released from the rabbit tibia-fibula system by the cutting method. It is found that the observed residual stress is comparable to that by the selfweight and its distribution is complex over the tibia. A model was proposed for the bone remodeling permitting the existence of the residual stress in the bone. The basic capability of the model was examined by simple case studies combined with the observed residual stress.2. Experimental spondylosis model and effect of overuseThe experimental spondylosis was established by surgicalintervention in mice. Mechanical instability accelerates the process of intervertebral disc degeneration and the long term instability brings the spondylosis. Repetitive extension-flexion was loaded on spine of rabbits, and the delamination of annulus fibrosus and the early osteophyte formation are observed. This suggests the overuse is a factor in the pathogenesis of spondylosis.3. Mechanical adaptation of aorta and patellar tendonGoldblatt hypertension was induced in rats and it is found that the aortic wall changes in morphology first and then in the mechanical properties adoptng itself to the mechanical environment. The stress shielding in the patellar tendon of rabbits leads the immediate decrease of the mechanical properties and the reloading brings the gradual recovery. These results show the rapid mechanical adaptation in soft tissues.

生物问题和系统具有根据其环境和日常行为的变化而生长、吸收和/或变形的能力。这种通过重塑进行机械适应的能力只有在生物学问题和系统中才具有。定量观测及其模型描述是理解此类现象并将其应用于工程领域的基础。从这一角度出发，本研究从实验/数学的角度探讨了以下几个问题。骨内残馀应力及重建模型用切割法从兔胫腓骨系统释放残馀应力。结果表明，观测到的残余应力与自重的残余应力相当，且在胫骨上的分布比较复杂。提出了一种考虑残馀应力影响的骨重建模型。通过简单的案例研究，结合观测到的残余应力检验了模型的基本能力。实验性脊椎病模型及过度使用的影响通过手术干预建立小鼠实验性脊椎病模型。机械失稳加速了椎间盘退变的进程，长期失稳会导致椎体退变。对兔脊柱进行反复屈伸载荷，观察纤维环的分层和早期骨赘的形成。提示过度使用是脊椎病发病机制中的一个因素。在Goldblatt高血压大鼠模型上发现，主动脉壁在形态上先发生改变，然后才发生适应力学环境的力学性质的改变。兔髌腱的应力遮挡导致力学性能即刻下降，再加载后逐渐恢复。这些结果表明软组织具有快速的机械适应能力。