Descending projections of the hypothalamic paraventricular nucleus

下丘脑室旁核的下降投射

• 批准号: 02670026
• 负责人: HOSOYA Yasuhiko
• 金额: $ 1.41万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670026/
• 关键词: Hypothalamus; Paraventricular nucleus; Sympathetic preganglionic neurons; PHA-L; Choleratoxin; A5 group; Descending pathway; Superior salivatory nucleus; 免疫組織化学; A5群

The descending projections from the hypothalamic paraventricular nucleus(PVN)to the A5 adrenergic neurons, the superior salivatory nucleus neurons and the sympathetic preganglionic neurons were studied.1)PVN-projections to the superior salivatory nucleus : PVN-fibers were labeled by anterograde transport of PHA-L, while superior salivatory nucleus neurons were retrogradely labeled by HRP which was applied to the greater petrosal nerve. A5 adrenergic neurons were demonstrated by immunohistochemistry for catecholamine synthetizing enzyme(DBH). PVN-fibers with varicosities were exclusively. found within the area of the superior salivatory nucleus, while terminals or varicosities were occasionally observed in close relation to A5 adrenergic neurons.2)PVN-fibers to the sympathetic preganglionic neurons : PVN-fibers were labeled anterogradely by PHA-L, while the sympathetic preganglionic neurons were labeled retrogradely by choleratoxin subunit B which was injected in the superior cervical ganglion. PVN-fibers with terminals and varicosities were occasionally found in contiguity with the dendrites of the sympathetic preganglionic neurons which were located in the central autonomic area dorsal to the central canal.These results suggest that the hypothalamic paraventricular nucleus is involved in regulation of activities of the autonomic nervous system, both oi parasympathetic and sympathetic nerves.

研究了下丘脑室旁核（PVN）向A5肾上腺素能神经元、上级唾液核神经元和交感节前神经元的下行投射：1）PVN向上级唾液核的投射：PVN纤维由PHA-L顺行标记，而上级唾液核神经元则由HRP逆行标记。A5肾上腺素能神经元用免疫组织化学方法检测。PVN-纤维静脉曲张是唯一的。PVN纤维与交感节前神经元的关系：PVN纤维被PHA-L顺向标记，交感节前神经元被注射到颈上级神经节的霍乱毒素B亚单位逆向标记。在中央管背侧的中央自主神经区，偶见有终末和静脉曲张的PVN纤维与交感节前神经元的树突邻接，提示下丘脑室旁核参与自主神经系统的活动，包括副交感神经和交感神经。

项目成果

Hosoya et al.: "Morphology of sympathetic preganghionic neurons innervating the superior cervical ganglion in the chicken:an immunolnistochomical study using retrograde lakeling of cholera toxin subunit B." Experimental Brain Research. (1992)

Hosoya 等人：“支配鸡颈上神经节的交感神经节前神经元的形态：利用霍乱毒素 B 亚基逆行湖化的免疫组学研究。”

Hosoya Y., Yaginuma H., Okado N. and Kohno K.: "Morphology of sympathetic preganglionic neurons innervating the superior cervical ganglion in the chiken : an immunohistochemical study using retrograde labeling of cholera toxin subunit B." Experimental Bra

Hosoya Y.、Yaginuma H.、Okado N. 和 Kohno K.：“支配鸡颈上神经节的交感神经节前神经元的形态：使用霍乱毒素 B 亚基逆行标记的免疫组织化学研究。”

Hosoya et al.: "Descending projections from the hypothalamic paraventricular nucleus to the A_5 area,including the superior salivatory nucleus." Experimental Brain Research. 82. 513-518 (1990)

Hosoya 等人：“从下丘脑室旁核到 A_5 区域的下降投影，包括上唾液核。”

Okada et al.: "Retrograde neuronal labelling by E.Coli enterotoxir subunit B." Neuroscience Letters. 120. 263-266 (1990)

Okada 等人：“大肠杆菌肠毒素 B 亚基逆行神经元标记。”

Hosoya et al.: "Coincidence of "ladder-like patterns" in distributions of monoaminergic terminals and sympathetic preganglionic neurons in the rat spinal cord." Experimental Brain Research. 86. 224-228 (1991)

Hosoya 等人：“大鼠脊髓中单胺能末梢和交感神经节前神经元分布的‘梯状模式’的重合。”