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Brainstem mechanisms of otolith-visual interaction in the control of eye movement produced by sinusoidal vertical linear acceleration

正弦垂直线性加速度产生的眼球运动控制中耳石-视觉相互作用的脑干机制

基本信息

批准号：
02670044
负责人：
FUKUSHIMA Kikuro
金额：
$ 1.34万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

Eye movement responses were examined in alert during sinusoidal vertical linear acceleration at 0.20-0.85Hz with an amplitude of 10.5cm (corresponding to 0.02-0.31g). Sinusoidal linear acceleration in the light produced robust eye movement responses with near compensatory phase at all stimulus frequencies tested. In the dark, however, only small responses with advanced phase (by 70ﾟ) were obtained. Optokinetic stimulation alone produced more lag of response phase with smaller gain as stimulus frequency increased. Linear acceleration in cats that had received bilateral labyrinthectomies resulted in more phase lag at higher stimulus frequencies and decreased gain at all frequencies tested. These results indicate that the interaction of otolith and visual inputs produces robust eye movement responses with near compensatory phase during sinusoidal linear acceleration in the light.To examine brainstem mechanisms for this interaction, neuronal activity was recorded in the interstitial nucleu … More s of Cajal (INC) and vestibular nuclei (VN). Activity of all eye movement-related burst-tonic (BT) and tonic (T) neurons in the INC was modulated in correlation to eye movement responses in the light. However, in the dark, most of them (84%) did not respond. The remaining cells responded to linear acceleration ; their mean phase values advanced by 801 and gain dropped by 55% compared to the responses in the light. These results suggest that the otolith-visual interaction occurs before the level of these neurons. Many INC cells other than BT and T cells responded to linear acceleration in the dark and optokinetic stimulation, indicating that these cells received otolith and visual inputs. Responses of some of these cells during linear acceleration in the light could be explained by addition of otolith and visual inputs. Many VN cells that responded to pitch rotation, including cells with vertical eye position sensitivity, did not respond to linear acceleration in the dark. A minority of VN cells responded to linear acceleration in the dark. These results suggest that the otolith-visual interaction may occur both in the INC and VN at neurons that do not have eye position sensitivity. Less

在0.20~0.85赫兹、10.5 cm(对应0.02~0.31g)的正弦垂直线加速度作用下，观察眼动反应。在所有被测试的刺激频率下，光中的正弦线性加速产生了强健的眼动反应，具有接近补偿的相位。然而，在黑暗中，只获得了超前相位(70ﾟ)的小响应。随着刺激频率的增加，单纯视动刺激引起的反应时相延迟较大，增益较小。在接受双侧迷路切除的猫中，线性加速导致在较高刺激频率下更多的相位滞后，并在所有测试频率下降低增益。这些结果表明，耳石和视觉输入的相互作用产生了强健的眼动反应，在光线下的正弦线性加速过程中，眼动反应接近代偿期。为了研究这种相互作用的脑干机制，在间质核…记录了神经元的活动更多的是Cajal(Inc.)和前庭核团(VN)的S。INC中所有与眼动相关的爆发性强直(BT)和强直(T)神经元的活动都受到与光线下眼动反应相关的调节。然而，在黑暗中，大多数人(84%)没有反应。其余的细胞对线性加速做出反应；与光下的反应相比，它们的平均相位值提前了801，增益下降了55%。这些结果表明，耳石-视觉相互作用发生在这些神经元的水平之前。除BT和T细胞外，许多INC细胞对暗刺激和视动刺激中的线性加速反应，表明这些细胞接受了耳石和视觉输入。其中一些细胞在光线中线性加速时的反应可以用耳石和视觉输入的增加来解释。许多对俯仰旋转有反应的VN细胞，包括对垂直眼位敏感的细胞，在黑暗中对线性加速没有反应。少数VN细胞对黑暗中的直线加速反应。这些结果表明，耳石-视觉相互作用可能发生在INC和VN中不具有眼位敏感性的神经元。较少