Roles of caudal frontal eye fields (FEF) in representation of visual information in space : Comparison with MT/MST.

尾部额叶视野 (FEF) 在空间视觉信息表示中的作用：与 MT/MST 的比较。

基本信息

批准号：
12480244
负责人：
FUKUSHIMA Kikuro
金额：
$ 9.34万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

Recent studies show that caudal parts of the frontal eye fields(FEF)contain smooth pursuit neurons. FEF has reciprocal connections with the cortical MT and MST. To understand the FEF role in representation of visual information and pursuit eye movements in space, I examined whether FEF pursuit neurons also respond to vergence eye movements and compared their activity with that in MT/MST. Head-fixed Japanese monkeys were trained to pursue a spot that moved in frontal planes and depth. I tested 155 neurons in FEF and 143 neurons in MT/MST during both frontal pursuit and vergence(I. E. depth pursuit). Majority of FEF neurons(66%)modulated strongly during both frontal and depth pursuit, resulting in three dimensional(3D) Cartesian representation of eye movements. Although MT/MST contained neurons that responded during both frontal and depth pursuit, the percentage of such neurons was much less(12%)compared to that in FEF. Majority of MT/MST neurons responded only during frontal pursuit(76% vs 26% in FEF). Visual response to sinusoidal motion of a virtual spot or optic flow was compared while the animals fixated a stationary spot. Majority of FEF neurons tested(33/61)responded to spot motion and flow in frontal plane and/or depth with visual preferred directions similar to those during pursuit. In contrast, majority of MT/MST neurons tested(57/106)responded to optic flow and spot motion with preferred directions opposite to those during pursuit. These differences between neurons in FEF and MT/MST suggest different roles for the two cortical areas in pursuit and support the view that 3D pursuit signals are synthesized mainly in FEF.

最近的研究表明，额眼场（FEF）的尾部部分包含平滑的追捕神经元。 FEF与皮质MT和MST具有相互连接。为了了解FEF在表示空间中的视觉信息和追捕眼运动中的作用，我检查了FEF追捕神经元是否也对Gergence眼动作做出反应，并将其活动与MT/MST中的活动进行了比较。头部固定的日本猴子经过训练，可以追求一个在额叶和深度上移动的地方。我在FEF中测试了155个神经元，并在额叶追捕和Gergence期间（即E. E. Depth Persuit）测试了MT/MST的143个神经元。大多数FEF神经元（66％）在额叶和深度追踪过程中都强烈调节，导致眼睛运动的三维（3D）笛卡尔表示。尽管MT/MST的神经元在额叶和深度追踪过程中都作出反应，但与FEF相比，这种神经元的百分比要小得多（12％）。大多数MT/MST神经元仅在额叶追捕过程中做出反应（FEF为76％vs 26％）。在固定固定位置时，比较了虚拟点或光流的正弦运动的视觉响应。经过测试的大多数FEF神经元（33/61）对额叶平面和/或深度的响应响应，其视觉优选方向与追捕过程中的相似。相反，大多数经过测试的MT/MST神经元（57/106）对视觉流动和点运动的反应与追捕过程中相反的选择方向相反。 FEF和MT/MST中神经元之间的这些差异提出了两个皮质区域的不同作用，并支持3D追求信号主要在FEF中合成的观点。