Role of the cerebellar floccular lobe and vermis in vertical smooth pursuit eye movement

为了解绒球叶是如何参与垂直平滑追踪和前庭眼反射（VOR）的，我们检测了58个垂直浦肯野（P-）细胞的简单锋电位活动。垂直注视速度（VG）P细胞仅占垂直P细胞的少数（19%）。在俯仰VOR抑制期间响应的其他P细胞被分类为眼和头速度（VE/H）P细胞（48%），而不管它们在追踪和VOR抑制期间的响应方向的协同作用。在俯仰VOR抑制期间不响应但在垂直平面中旋转期间响应而不是俯仰的垂直P细胞被分类为非俯仰VE/HP细胞（33%）。3种垂直P细胞的平均眼速度和眼位置敏感性相似。在VOR抑制过程中，通过垂直全身旋转，使猴子处于不同的垂直平面，检查最大前庭激活方向（MAD）。VGP-和V E/HP-细胞的MAD与眼和 关于我们 前庭感觉在同一方向上分布于音高平面附近，提示双侧前半规管输入的会聚。相反，偏距V-E/HP细胞和V-E/HP细胞具有相反方向的眼和前庭敏感性的MAD向滚动平面移动，表明同侧的前、后通道输入会聚。与水平GP细胞不同，当目标在空间中固定（俯仰VOR × 1）时，许多VG和VE/HP细胞的调制不能很好地通过它们在垂直追踪和俯仰VOR抑制期间的调制的线性相加来预测。这些结果表明，垂直和水平眼动P细胞的群体在絮状叶有显着不同的放电特性。在小脑蚓部使用相同的范例记录显示许多G P-细胞倾斜的首选方向。这些结果表明，这两个结构参与不同类型的处理前庭-眼的相互作用。少

To understand how the floccular lobe is involved in vertical smooth pursuit and vestibulo-ocular reflex (VOR), we examined simple-spike activity of 58 vertical Purkinje (P-) cells. Vertical gaze velocity (VG) P-cells constituted only a minority of vertical P-cells (19%). Other P-cells that responded during pitch VOR suppression were classified as eye and head velocity (V E/H) P-cells (48%), regardless of the synergy of their response direction during pursuit and VOR suppression. Vertical P-cells that did not respond during pitch VOR suppression but responded during rotation in vertical planes other than pitch were classified as off-pitch V E/H P-cells (33%). The mean eye-velocity and eye-position sensitivities of the 3 types of vertical P-cells were similar. Maximal vestibular activation directions (MADs) were examined during VOR suppression by applying vertical whole body rotation with the monkeys oriented in different vertical planes. The MADs for VGP- and V E/H P-cells with eye and … More vestibular sensitivity in the same direction were distributed near the pitch plane, suggesting convergence of bilateral anterior canal inputs. In contrast, MADs of off-pitch V E/ HP-cells and V E/H P-cells with oppositely directed eye and vestibular sensitivity were shifted towards the roll plane, suggesting convergence of anterior and posterior canal inputs of the same side. Unlike horizontal GP-cells, the modulation of many V G and V E/H P-cells when the target was fixed in space (pitch VOR x1) was not well predicted by the linear addition of their modulations during vertical pursuit and pitch VOR suppression. These results indicate that the populations of vertical and horizontal eye-movement P-cells in the floccular lobe have markedly different discharge properties. Recordings in the cerebellar vermis using identical paradigms revealed many G P-cells with oblique preferred directions. These results suggest that these two structures are involved in different kinds of processing of vestibular-oculomotor interactions. Less