Role of the cerebellar floccular lobe and vermis in vertical smooth pursuit eye movement

为了了解絮体叶如何参与垂直平滑追求和前庭眼反射（VOR），我们检测了58个垂直浦肯野（P-）细胞的单峰活性。垂直凝视速度（VG） p细胞仅占垂直p细胞的少数（19%）。其他在俯仰VOR抑制过程中有反应的p细胞被归类为眼速和头速（V E/H） p细胞（48%），而不考虑它们在追逐和VOR抑制过程中反应方向的协同作用。垂直p细胞在俯仰VOR抑制期间没有反应，但在俯仰以外的垂直平面旋转期间有反应，被归类为离俯仰V E/H p细胞（33%）。3种垂直p细胞的平均眼速和眼位敏感性相似。在不同的垂直平面上，采用全身垂直旋转的方法，观察了在VOR抑制过程中猴子的最大前庭激活方向。VGP-和ve /H -细胞的MADs在同一方向上更多的前庭敏感性分布在音高平面附近，提示双侧前管输入趋同。相反，非俯仰的V E/ hp -细胞和相反方向的眼和前庭敏感的V E/ hp -细胞的MADs向滚动面移动，表明同侧的前后管输入趋同。与水平gp -cell不同，当目标在空间中固定（俯仰VOR x1）时，许多V - G和V - E/H -cell的调制不能通过垂直跟踪和俯仰VOR抑制期间的调制线性相加来很好地预测。这些结果表明，眼动细胞在絮叶内的垂直和水平分布具有明显不同的放电特性。在小脑蚓部使用相同的范式记录显示许多pg细胞具有倾斜的优先方向。这些结果表明，这两个结构参与了前庭-动眼肌相互作用的不同加工。少

To understand how the floccular lobe is involved in vertical smooth pursuit and vestibulo-ocular reflex (VOR), we examined simple-spike activity of 58 vertical Purkinje (P-) cells. Vertical gaze velocity (VG) P-cells constituted only a minority of vertical P-cells (19%). Other P-cells that responded during pitch VOR suppression were classified as eye and head velocity (V E/H) P-cells (48%), regardless of the synergy of their response direction during pursuit and VOR suppression. Vertical P-cells that did not respond during pitch VOR suppression but responded during rotation in vertical planes other than pitch were classified as off-pitch V E/H P-cells (33%). The mean eye-velocity and eye-position sensitivities of the 3 types of vertical P-cells were similar. Maximal vestibular activation directions (MADs) were examined during VOR suppression by applying vertical whole body rotation with the monkeys oriented in different vertical planes. The MADs for VGP- and V E/H P-cells with eye and … More vestibular sensitivity in the same direction were distributed near the pitch plane, suggesting convergence of bilateral anterior canal inputs. In contrast, MADs of off-pitch V E/ HP-cells and V E/H P-cells with oppositely directed eye and vestibular sensitivity were shifted towards the roll plane, suggesting convergence of anterior and posterior canal inputs of the same side. Unlike horizontal GP-cells, the modulation of many V G and V E/H P-cells when the target was fixed in space (pitch VOR x1) was not well predicted by the linear addition of their modulations during vertical pursuit and pitch VOR suppression. These results indicate that the populations of vertical and horizontal eye-movement P-cells in the floccular lobe have markedly different discharge properties. Recordings in the cerebellar vermis using identical paradigms revealed many G P-cells with oblique preferred directions. These results suggest that these two structures are involved in different kinds of processing of vestibular-oculomotor interactions. Less