权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Role of the cerebellar floccular region in generation of three dimensional pursuit eye movements - Comparison with frontal eye field signals -

小脑絮状区域在三维追踪眼球运动生成中的作用 - 与额叶眼场信号的比较 -

基本信息

批准号：
16300128
负责人：
FUKUSHIMA Kikuro
金额：
$ 9.66万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Frontal-eyed primates use both smooth-pursuit in frontal planes (frontal-pursuit) and pursuit-in-depth (vergence-pursuit) to track objects of interest moving slowly in three-dimensional (3D) space. The cerebellar floccular region is well known to play a crucial role in initiation and maintenance of frontal-pursuit and control of the vestibulo-ocular reflex (VOR). By assigning monkeys to pursue a spot moving in 3D space, I examined whether pursuit Purkinje (P) cells in the floccular region have vergence sensitivity and how they are involved in vergence-pursuit. Of 112 pursuit P cells examined for both frontal and vergence-pursuit, the majority (63%) discharged for both, 24% discharged only for vergence-pursuit and 13% discharged only for frontal-pursuit. The majority of (58%) of vergence-related P cells had velocity sensitivity, thus they carry 3D-pursuit signals. 72% also had vergence-position sensitivity. In contrast, pursuit P cells that discharged specifically for frontal-pursuit ar … More e in the minority in the floccular region. 80% of 3D-pursuit P cells discharged after the onset of vergence-pursuit with the average lag of 56 ms. I also examined activity of floccular P cells during fore/aft translation to test whether they carry gaze-velocity signals. The majority of P cells (17/22=77%) did not respond to fore/aft translation when monkeys were required to fixate a target that moved with them in order to maintain the vergence angle during translation. However, most (13/22=59%) responded if the monkeys were required compensatory vergence eye movements. Actual responses during the latter condition were well predicted by their eye velocity sensitivity during vergence-pursuit. These results suggest the involvement of the floccular region in 3D-pursuit rather than gaze (eye-in-space) control. Pursuit signals in the floccular region could provide internal feedback signals for pursuit gain control. Vergence eye position-related P cell activity could also provide the viewing distance information for appropriate control of the VOR. Less

额眼灵长类动物使用额面平滑追踪(Frontal-Purching)和深度追踪(Version-Purching)来跟踪感兴趣的物体在三维空间中的缓慢移动。众所周知，小脑绒毛区在前庭-眼反射(VOR)的启动和维持以及前庭-眼反射(VOR)的控制中起着至关重要的作用。通过分配猴子在3D空间中追逐一个移动的点，我检查了绒毛区的Purkinje(P)细胞是否具有收敛敏感性，以及它们是如何参与收敛追逐的。在112个追踪P细胞中，大多数(63%)同时接受正面追踪和收敛追踪，24%的细胞仅因追踪追踪而出院，13%的细胞仅因正面追赶而出院。大多数(58%)与收敛相关的P细胞具有速度敏感性，因此它们携带3D追踪信号。72%的患者对会聚位置敏感。相比之下，专为正面追踪AR…放电的追踪P细胞绒毛区少数E较多。80%的三维追踪P细胞在快速追踪开始后放电，平均延迟为56ms。我还检测了前后平移过程中绒毛P细胞的活性，以测试它们是否携带凝视速度信号。大多数P细胞(17/22=77%)对平移前后没有反应，要求猴子注视与它们一起移动的目标以保持平移时的聚集角。然而，大多数(13/22=59%)的人在要求猴子进行补偿性眼球运动时做出了回应。在后一种情况下，他们的眼速敏感度可以很好地预测后一种情况下的实际反应。这些结果表明，絮状区参与了3D追踪，而不是凝视(眼睛在空间中的)控制。絮状区的跟踪信号可以为跟踪增益控制提供内部反馈信号。与眼部位置相关的P细胞活动也可以提供视距信息，以便适当控制VOR。较少