Role of the cerebellar floccular region in generation of three dimensional pursuit eye movements - Comparison with frontal eye field signals -

小脑絮状区域在三维追踪眼球运动生成中的作用 - 与额叶眼场信号的比较 -

基本信息

批准号：
16300128
负责人：
FUKUSHIMA Kikuro
金额：
$ 9.66万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Frontal-eyed primates use both smooth-pursuit in frontal planes (frontal-pursuit) and pursuit-in-depth (vergence-pursuit) to track objects of interest moving slowly in three-dimensional (3D) space. The cerebellar floccular region is well known to play a crucial role in initiation and maintenance of frontal-pursuit and control of the vestibulo-ocular reflex (VOR). By assigning monkeys to pursue a spot moving in 3D space, I examined whether pursuit Purkinje (P) cells in the floccular region have vergence sensitivity and how they are involved in vergence-pursuit. Of 112 pursuit P cells examined for both frontal and vergence-pursuit, the majority (63%) discharged for both, 24% discharged only for vergence-pursuit and 13% discharged only for frontal-pursuit. The majority of (58%) of vergence-related P cells had velocity sensitivity, thus they carry 3D-pursuit signals. 72% also had vergence-position sensitivity. In contrast, pursuit P cells that discharged specifically for frontal-pursuit ar … More e in the minority in the floccular region. 80% of 3D-pursuit P cells discharged after the onset of vergence-pursuit with the average lag of 56 ms. I also examined activity of floccular P cells during fore/aft translation to test whether they carry gaze-velocity signals. The majority of P cells (17/22=77%) did not respond to fore/aft translation when monkeys were required to fixate a target that moved with them in order to maintain the vergence angle during translation. However, most (13/22=59%) responded if the monkeys were required compensatory vergence eye movements. Actual responses during the latter condition were well predicted by their eye velocity sensitivity during vergence-pursuit. These results suggest the involvement of the floccular region in 3D-pursuit rather than gaze (eye-in-space) control. Pursuit signals in the floccular region could provide internal feedback signals for pursuit gain control. Vergence eye position-related P cell activity could also provide the viewing distance information for appropriate control of the VOR. Less

额眼的私人同时使用额平面（额叶行李）和深度追踪（gergence-pursuit）的平滑行李，以跟踪感兴趣的对象在三维（3D）空间中缓慢移动。众所周知，小脑絮状区域在额叶行李的启动和维持和控制性的眼镜反射（VOR）中起着至关重要的作用。通过分配猴子以追求在3D空间中移动的斑点，我检查了引起引中区域中的Purkinje（P）细胞是否具有敏感性以及它们如何参与Gergence-Pursuit。在检查额叶和格式 - 伪装的112个追捕P细胞中，大多数（63％）均出院，仅针对gergence-pursuit出院24％，而仅用于额叶行李的13％。（58％）与Gergence相关的P细胞中的大多数具有速度敏感性，因此它们具有3D-Pursuit信号。 72％的敏感性也具有GRGENCE位置敏感性。相比之下，在絮状区域的少数群体中，专门为额叶行李箱AR排出的追捕P细胞。在Gergence-Pursuit发作后，3D-pursuit P细胞中有80％的平均滞后时间为56毫秒。我还检查了絮状细胞在前/后尾翻译过程中的活性，以测试它们是否携带凝视速度信号。当需要猴子固定与它们移动的目标以保持翻译过程中的捕获角度时，大多数P细胞（17/22 = 77％）没有响应前/后的翻译。但是，如果需要猴子的补偿性眼球运动，大多数（13/22 = 59％）会做出反应。在稍后条件下的实际反应通过其眼睛速度灵敏度在Gergence-Pursuit期间很好地预测。这些结果表明，絮状区域参与了3D-锻件，而不是凝视（空间空间）的控制。絮状区域的追捕信号可以提供内部反馈信号，以控制追求增益。与Gergence眼睛位置相关的P细胞活性也可以提供观看距离信息，以适当控制VOR。较少的

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Adaptive changes in vergence eye movements induced by vergence-vestibular interaction training in monkeys.

猴子的聚散-前庭交互训练引起的聚散眼球运动的适应性变化。

DOI：
发表时间：
2004
期刊：
Exp.Brain Res. 156
影响因子：
0
作者：
Sato;F.
通讯作者：
F.

Prediction in the timing of pursuit eye movement initiation revealed by cross-axis vestibular-pursuit training in monkeys.

通过猴子的横轴前庭追踪训练揭示追踪眼动启动时间的预测。

DOI：
发表时间：
2006
期刊：
Experimental Brain Res 168
影响因子：
0
作者：
Fukushima;J;Tsubuku T
通讯作者：
Tsubuku T

Role of vestibular signals in the caudal part of the frontal eye fields in pursuit eye movements in three-dimensional space.

前庭信号在额眼场尾部在三维空间中追踪眼球运动中的作用。

DOI：
发表时间：
2005
期刊：
Ann NY Acad Sci 1039
影响因子：
0
作者：
Akao T;Mustari MJ;Fukushima J;Kurkin S;Fukushima K;Akao T;Akao T;Miyamaoto T;Fukushima K
通讯作者：
Fukushima K

Further evidence for selective difficulty of upward eye pursuit in young monkeys : effects of optokinetic stimulation, static roll tilt, and active head movements.

幼猴向上眼球追踪选择性困难的进一步证据：视动刺激、静态滚动倾斜和主动头部运动的影响。