Brainstem mechanisms in vertical eye movement

垂直眼球运动的脑干机制

基本信息

批准号：
61570057
负责人：
FUKUSHIMA Kikuro
金额：
$ 1.28万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

In order to study a role of the interstitial nucleus of Cajal (INC) in vertical eye movements, single cell recording was obtained in alert cats. Neurons were classified into 4 groups; vertical burst-tonic (51.5 %), tonic (12.9 %),burst (3.8 %) neurons, and the remaining cells that did not belong to any of these three groups but that were activated by pitch rotations (31.8 %). Discharge frequencies of burst-tonic and tonic neurons were linearly correlated with vertical eye position, and more than a half of them projected near the vestibular nuclei, suggesting that vertical eye position signal is carried back to the vestibular nuclei from the INC.Neuronal activity was examined in the INC region during adaptive gain change of the vertical vestibulo-ocular reflex (VOR). The vertical recti muscles of one eye were weakened by tenectomy, and the weak eye was continuously covered with a metal patch to prevent vision. When the patch was switched to the normal eye so that the weak eye was viewing while pitch rotations were continuously applied, the vertical VOR gain showed a gradual and significant increase within 1 hour. When the patch was switched to the weak eye so that the normal eye started viewing again, the VOR gain quickly decreased to the control values. Since such reversible gain change was not observed without visual input, these changes are adaptive changes to reduce visual-vestibular conflict. During such adaptive gain change, all the vertical burst-tonic and tonic neurons tested showed significant changes in response amplitudes in parallel with the change in the VOR gain, suggesting that they may send the altered VOR gain signal to the vestibular nuclei. These results suggest that the central feedback which sends eye position signal from the INC to the vestibular nuclei is involved in the neural integration of the vertical VOR in normal and adapted cats.

为了研究Cajal（INC）在垂直眼运动中的间质核的作用，在警报猫中获得了单细胞记录。神经元分为4组；垂直爆发（51.5％），补品（12.9％），爆发（3.8％）神经元以及不属于这三组中的任何一个但被沥青旋转激活的细胞（31.8％）。 Discharge frequencies of burst-tonic and tonic neurons were linearly correlated with vertical eye position, and more than a half of them projected near the vestibular nuclei, suggesting that vertical eye position signal is carried back to the vestibular nuclei from the INC.Neuronal activity was examined in the INC region during adaptive gain change of the vertical vestibulo-ocular reflex (VOR).一只眼睛的垂直直肠肌肉被骨切除术削弱，弱眼睛被金属斑块连续覆盖以防止视力。当贴片切换到正常的眼睛，以便在连续使用俯仰旋转时观看弱的眼睛时，垂直的VOR增益在1小时内显示出逐渐且显着增加。当贴片切换到弱眼，以便正常的眼睛再次开始观看时，VOR增益很快就会降低到控制值。由于没有视觉输入就不会观察到这种可逆的增益变化，因此这些变化是自适应变化，以减少视觉范围的冲突。在这种自适应增益变化期间，所有测试的垂直爆发和补品神经元与VOR增益的变化并联响应幅度的显着变化，这表明它们可能会将VOR增益信号变化的VOR增益信号发送给前庭核。这些结果表明，将眼睛位置信号从INC发送到前庭核的中心反馈参与正常和适应性猫的垂直VOR的神经整合。