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Brainstem mechanisms in vertical eye movement

垂直眼球运动的脑干机制

基本信息

批准号：
61570057
负责人：
FUKUSHIMA Kikuro
金额：
$ 1.28万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

In order to study a role of the interstitial nucleus of Cajal (INC) in vertical eye movements, single cell recording was obtained in alert cats. Neurons were classified into 4 groups; vertical burst-tonic (51.5 %), tonic (12.9 %),burst (3.8 %) neurons, and the remaining cells that did not belong to any of these three groups but that were activated by pitch rotations (31.8 %). Discharge frequencies of burst-tonic and tonic neurons were linearly correlated with vertical eye position, and more than a half of them projected near the vestibular nuclei, suggesting that vertical eye position signal is carried back to the vestibular nuclei from the INC.Neuronal activity was examined in the INC region during adaptive gain change of the vertical vestibulo-ocular reflex (VOR). The vertical recti muscles of one eye were weakened by tenectomy, and the weak eye was continuously covered with a metal patch to prevent vision. When the patch was switched to the normal eye so that the weak eye was viewing while pitch rotations were continuously applied, the vertical VOR gain showed a gradual and significant increase within 1 hour. When the patch was switched to the weak eye so that the normal eye started viewing again, the VOR gain quickly decreased to the control values. Since such reversible gain change was not observed without visual input, these changes are adaptive changes to reduce visual-vestibular conflict. During such adaptive gain change, all the vertical burst-tonic and tonic neurons tested showed significant changes in response amplitudes in parallel with the change in the VOR gain, suggesting that they may send the altered VOR gain signal to the vestibular nuclei. These results suggest that the central feedback which sends eye position signal from the INC to the vestibular nuclei is involved in the neural integration of the vertical VOR in normal and adapted cats.

为了研究卡哈尔间质核 (INC) 在垂直眼球运动中的作用，在警觉的猫中获得了单细胞记录。神经元分为 4 组；垂直爆发强直（51.5％），强直（12.9％），爆发（3.8％）神经元，以及不属于这三组中任何一组但由音调旋转激活的其余细胞（31.8％）。突发强直和强直神经元的放电频率与垂直眼位呈线性相关，其中一半以上投射到前庭核附近，表明垂直眼位信号从 INC 传回前庭核。在垂直前庭眼反射 (VOR) 的自适应增益变化期间，检查了 INC 区域的神经元活动。一只眼睛的垂直直肌因肌腱切除术而变得虚弱，而虚弱的眼睛则持续被金属贴片覆盖以防止视力。当将贴片切换到正常眼，使弱眼观看，同时连续应用俯仰旋转时，垂直 VOR 增益在 1 小时内显示出逐渐且显着的增加。当将贴片切换到弱眼以使正常眼再次开始观看时，VOR 增益迅速下降到控制值。由于在没有视觉输入的情况下无法观察到这种可逆增益变化，因此这些变化是减少视觉前庭冲突的适应性变化。在这种适应性增益变化期间，所有测试的垂直突发强直和强直神经元都显示出与 VOR 增益变化平行的响应幅度的显着变化，表明它们可能将改变的 VOR 增益信号发送到前庭核。这些结果表明，将眼睛位置信号从 INC 发送到前庭核团的中枢反馈参与了正常猫和适应猫的垂直 VOR 的神经整合。