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Brainstem mechanisms in vertical eye movement

垂直眼球运动的脑干机制

基本信息

批准号：
61570057
负责人：
FUKUSHIMA Kikuro
金额：
$ 1.28万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

项目摘要

In order to study a role of the interstitial nucleus of Cajal (INC) in vertical eye movements, single cell recording was obtained in alert cats. Neurons were classified into 4 groups; vertical burst-tonic (51.5 %), tonic (12.9 %),burst (3.8 %) neurons, and the remaining cells that did not belong to any of these three groups but that were activated by pitch rotations (31.8 %). Discharge frequencies of burst-tonic and tonic neurons were linearly correlated with vertical eye position, and more than a half of them projected near the vestibular nuclei, suggesting that vertical eye position signal is carried back to the vestibular nuclei from the INC.Neuronal activity was examined in the INC region during adaptive gain change of the vertical vestibulo-ocular reflex (VOR). The vertical recti muscles of one eye were weakened by tenectomy, and the weak eye was continuously covered with a metal patch to prevent vision. When the patch was switched to the normal eye so that the weak eye was viewing while pitch rotations were continuously applied, the vertical VOR gain showed a gradual and significant increase within 1 hour. When the patch was switched to the weak eye so that the normal eye started viewing again, the VOR gain quickly decreased to the control values. Since such reversible gain change was not observed without visual input, these changes are adaptive changes to reduce visual-vestibular conflict. During such adaptive gain change, all the vertical burst-tonic and tonic neurons tested showed significant changes in response amplitudes in parallel with the change in the VOR gain, suggesting that they may send the altered VOR gain signal to the vestibular nuclei. These results suggest that the central feedback which sends eye position signal from the INC to the vestibular nuclei is involved in the neural integration of the vertical VOR in normal and adapted cats.

为了研究Cajal间质核（INC）在垂直眼球运动中的作用，在警觉猫上获得了单细胞记录。神经元分为4组：垂直爆发-强直（51.5%），强直（12.9%），爆发（3.8%）神经元，其余细胞不属于这三组中的任何一组，但被音高旋转激活（31.8%）。爆发性紧张性和紧张性神经元的放电频率与垂直眼位置呈线性相关，其中一半以上的前庭核附近的投影，这表明垂直眼位置信号进行回前庭核从INC。神经元活动的INC区域进行了检查，在自适应增益变化的垂直前庭眼反射（VOR）。一只眼的垂直直肌通过肌腱切除术减弱，虚弱的眼睛持续覆盖金属贴片以防止视力。当贴片切换到正常眼，使弱眼观看，同时连续施加俯仰旋转时，垂直VOR增益在1小时内显示出逐渐且显著的增加。当贴片切换到弱眼，使正常眼再次开始观看时，VOR增益迅速降低到控制值。由于在没有视觉输入的情况下没有观察到这种可逆的增益变化，因此这些变化是减少视觉-前庭冲突的自适应变化。在这种适应性增益变化过程中，所有测试的垂直爆发性紧张性和紧张性神经元的反应幅度与VOR增益的变化平行地显示出显著的变化，这表明它们可能将改变的VOR增益信号发送到前庭核。这些结果表明，正常猫和适应猫的垂直VOR的神经整合过程中，都有将眼位信号从INC传递到前庭核的中枢反馈参与。