Pathophysiological Research of Cochlear efferent System

耳蜗传出系统的病理生理学研究

• 批准号: 02670756
• 负责人: OHYAMA Kenji
• 金额: $ 1.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670756/
• 关键词: Efferent innervation; Cochlear physiology; Otoacoustic emissions; Sensorineural hearing Loss; Distortion-product emissions; 歪成分耳音響放射; 蝸牛

1)Investigation of cochlear physiology under derangement of efferent control system was conducted using otoacoustic emissions(OAEs)as an objective measure of the cochlear function. As the first step, an acoustic measuring system for known 4 classes of OAEs was constructed. In this series of research, many spontaneous OAE signals from guinea pigs, that had been regarded as extremely rare phenomenon, were closely examined. Basic features of guinea pig SOAEs were described and published. Efferent system did not look to affect on the SOAE in this animal.2)As an application of the acoustic measuring system which was established in the starting ear of the project, the distortion-product(DP)OAE was measured in normal and hearing-impaired ears. The DP audiogram was proved to be an excellent indicator of cochlear functional integrity. It provides frequencyspecific information of the cochlear physiology. However, the DP audiometry was not powerful enough to specify particular origin of a cochlear pathology. Further investigation seemed to be necessary before we can extract such an information from the DP audiometry.

1)本文用耳声发射（OAEs）作为耳蜗功能的客观指标，研究传出神经系统紊乱时耳蜗的生理变化。作为第一步，声学测量系统的已知的4类OAE的构建。在这一系列的研究中，许多自发的OAE信号，从豚鼠，一直被认为是非常罕见的现象，仔细检查。描述并发表了豚鼠SOAE的基本特征。传出系统似乎不会影响该动物的SOAE。2）作为在该项目的起始耳中建立的声学测量系统的应用，测量了正常耳和听力受损耳的失真产物（DP）OAE。DP听力图被证明是耳蜗功能完整性的良好指标。它提供耳蜗生理的频率特异性信息。然而，DP测听不足以说明耳蜗病理的特定起源。进一步的调查似乎是必要的，我们可以提取这样的信息，从DP测听。

项目成果

Ohyama, K. et al.: "Spontaneous otoacoustic emissions in the guinea pig." Hearing Research. 56. 111-121 (1991)

Ohyama, K. 等人：“豚鼠的自发耳声发射。”

Takasaka, T. and Ohyama, K.: "Recent advances in the clinical application of otoacoustic emissions." Practica Otologica (Kyoto).

Takasaka, T. 和 Ohyama, K.：“耳声发射临床应用的最新进展。”

Wada, H., Ohyama, K. and Takasaka, T.: "Extraction of synchronous evoked otoacoustic emissions in normal subjects." Audiology Japan. 35. 56-63 (1992)

Wada, H.、Ohyama, K. 和 Takasaka, T.：“正常受试者同步诱发耳声发射的提取”。

和田 仁,大山 健二,高坂 知節: "ヒトにおけるsynchronous evoked otoacoustic emissionsの抽出" Audiology Japan. 35. 41-45 (1992)

Hitoshi Wada、Kenji Oyama、Chisetsu Kosaka：“人体同步诱发耳声发射的提取”日本听力学 35. 41-45 (1992)。

大山 健二,他: "歪成分耳音響放射(DPOAE)による蝸牛機能の評価" Audiology Japan. 35. 46-55 (1992)

Kenji Oyama 等人：“使用扭曲耳声发射 (DPOAE) 评估耳蜗功能”日本听力学 35. 46-55 (1992)。